Hailfinger Stephan, Schulze-Osthoff Klaus
Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.
Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, Tübingen, Germany.
J Invest Dermatol. 2021 Dec;141(12):2775-2777. doi: 10.1016/j.jid.2021.06.006. Epub 2021 Sep 23.
Dysfunctional autophagy is linked to various diseases, including psoriasis and atopic dermatitis. Recent evidence suggests that exposure of keratinocytes to TNF-α results in impaired autophagy and lysosomal function. The skin of patients with psoriasis and atopic dermatitis reveals a decreased expression of lysosomal cathepsins. Impaired autophagy is presumably involved in inflammation and disturbed keratinocyte differentiation, whereas stimulating autophagy might be a treatment option in inflammatory skin disease.
功能失调的自噬与多种疾病相关，包括银屑病和特应性皮炎。最近的证据表明，角质形成细胞暴露于肿瘤坏死因子-α会导致自噬和溶酶体功能受损。银屑病和特应性皮炎患者的皮肤显示溶酶体组织蛋白酶的表达降低。自噬受损可能参与炎症反应和角质形成细胞分化紊乱，而刺激自噬可能是炎症性皮肤病的一种治疗选择。
