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Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation.Gasdermin E 促进角质形成细胞中 p65 和 c-jun 向核内易位，从而促进银屑病皮肤炎症的进展。
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Nat Commun. 2023 Oct 25;14(1):6767. doi: 10.1038/s41467-023-42477-y.
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Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.通过靶向角质形成细胞中的 EDAR-NF-κB 信号通路，G9A 的耗竭可减轻咪喹莫特诱导的银屑病样皮炎。
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A Review on Caspases: Key Regulators of Biological Activities and Apoptosis.细胞凋亡蛋白酶综述：生物活性和细胞凋亡的关键调节剂。
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IL-17A-targeting fenofibrate attenuates inflammation in psoriasis by inducing autophagy.靶向白细胞介素-17A 的非诺贝特通过诱导自噬来减轻银屑病中的炎症反应。
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10
Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity.甲氨蝶呤通过抑制肽聚糖转运蛋白 SLC46A2 的活性来抑制银屑病皮肤炎症。
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程序性细胞死亡与银屑病之间的对话。

Dialogue between programmed cell death and psoriasis.

作者信息

Tian Jun, Zhang Lei, Yang Li

机构信息

Department of Dermatology, Shaanxi Provincial People's Hospital, Xi 'an, China.

出版信息

Postepy Dermatol Alergol. 2025 Feb;42(1):13-20. doi: 10.5114/ada.2024.147195. Epub 2025 Jan 29.

DOI:10.5114/ada.2024.147195
PMID:40114770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11921918/
Abstract

Psoriasis is a chronic inflammatory skin condition, associated with both physical and psychological burden. The aetiology of psoriasis is not fully understood. Physiologically programmed cell death (PCD) pathways are crucial for maintaining organismal homeostasis. Several investigations have highlighted the link between dysregulated PCD and the initiation of psoriasis. This review aims to outline various forms of programmed cell death pathways, encompassing the psoriasis distinctive features, triggers, implications in psoriasis pathogenesis, and therapeutic opportunities. It aspires to offer a comprehensive exploration of the role of programmed cell death in the context of psoriasis, providing a rational framework for further investigation and potential therapeutic interventions.

摘要

银屑病是一种慢性炎症性皮肤病，会给患者带来生理和心理负担。银屑病的病因尚未完全明确。生理性程序性细胞死亡（PCD）途径对于维持机体稳态至关重要。多项研究强调了PCD失调与银屑病发病之间的联系。本综述旨在概述程序性细胞死亡途径的各种形式，包括银屑病的独特特征、触发因素、在银屑病发病机制中的影响以及治疗机会。它希望能全面探讨程序性细胞死亡在银屑病中的作用，为进一步研究和潜在的治疗干预提供合理框架。