DeVoe Howard, Miller Michele M, Wasik Stanley P
National Bureau of Standards, Washington, DC 20234.
J Res Natl Bur Stand (1977). 1981 Jul-Aug;86(4):361-366. doi: 10.6028/jres.086.015.
Generator columns packed with a solid support and loaded with a liquid organic phase make it possible to rapidly and conveniently equilibrate water with the organic phase. By coupling the generator column to an extractor column for high pressure liquid chromatographic analysis of the aqueous solution, errors from surface adsorption and loss to the atmosphere are avoided. Using this method, the mean values and confidence limits at a 95 percent confidence level of the aqueous solubility, , and the octanol-water partition coefficient, , of n-propylbenzene at 25 °C were found to be = (4.32 ± 0.02) × 10 and log = 3.720 ± 0.003.
填充有固体载体并负载有液态有机相的发生器柱，使得水与有机相能够快速且方便地达到平衡。通过将发生器柱与用于水溶液高压液相色谱分析的萃取柱相连，可避免表面吸附和向大气中损失所导致的误差。使用该方法，在25℃下，正丙苯的水溶性（ ）和正辛醇 - 水分配系数（ ）的95%置信水平下的平均值和置信限分别为 = (4.32 ± 0.02) × 10 以及log = 3.720 ± 0.003。
