Krishnatry Rahul, Mangaj Akshay, Bhajbhuje Rajesh, Murthy Vedang
Department of Radiation Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
Homi Bhabha National Institute, Mumbai, Maharashtra, India.
J Med Phys. 2021 Apr-Jun;46(2):88-93. doi: 10.4103/jmp.JMP_120_20. Epub 2021 Aug 7.
To quantify the relative motion of pelvic and groin lymph nodes (PLN and GLN) and define indicative margins for image-guided radiotherapy based on bony anatomy for the frog-leg position (FLP) and groin immobilization board (GIB).
Twenty patients with planning computed tomography (CT) scan and on treatment cone beam CTs (median = 8) for groin and pelvic radiotherapy were included in the study. Of these nine were treated with FLP and eleven with GIB. The PLN and GLN regions on the left and right were outlined in each scan. Systematic and random uncertainties were determined along with correlations between the motions of these regions. The clinical target volume to planning target volume (PTV) margins required to take motion into account was calculated for each immobilization.
The mean shifts for PLN and GLN were lesser but not statistically lower using GIB over FLP. There was significant concordance in the vertical, longitudinal and lateral motion of the pelvis and right groin ( = 0.015, 0.09 and 0.049, respectively), pelvis and left groin ( = 0.001, 0.048, and 0.006, respectively) and between left and right groin ( = 0.013, 0.01 and 0.07, respectively) for FLP and not GIB. The PTV margins required by Van Herk and Stroom's formula were reduced from 11 mm and 9 mm to 6 mm and 5 mm for pelvis; 12 mm and 11 mm to 7 mm and 6 mm for groin, respectively, using FLP over GIB.
GIB brings concordance in shifts between pelvis and groin and between bilateral groins, thereby reducing the required PTV margins.
量化盆腔和腹股沟淋巴结(PLN和GLN)的相对运动,并根据蛙腿位(FLP)和腹股沟固定板(GIB)的骨骼解剖结构确定图像引导放射治疗的指示性边界。
本研究纳入了20例接受腹股沟和盆腔放射治疗的患者,这些患者均有计划计算机断层扫描(CT)以及治疗期间的锥形束CT(中位数=8)。其中9例采用FLP治疗,11例采用GIB治疗。在每次扫描中勾勒出左右两侧的PLN和GLN区域。确定系统和随机不确定性以及这些区域运动之间的相关性。计算每种固定方式下考虑运动所需的临床靶区到计划靶区(PTV)的边界。
使用GIB时,PLN和GLN的平均位移较小,但与FLP相比无统计学差异。对于FLP而非GIB,骨盆与右侧腹股沟(分别为=0.015、0.09和0.049)、骨盆与左侧腹股沟(分别为=0.001、0.048和0.006)以及左右腹股沟之间(分别为=0.013、0.01和0.07)在垂直、纵向和横向运动上存在显著一致性。使用FLP而非GIB时,Van Herk和Stroom公式所需的PTV边界,骨盆从11mm和9mm分别降至6mm和5mm;腹股沟从12mm和11mm分别降至7mm和6mm。
GIB使骨盆与腹股沟之间以及双侧腹股沟之间的位移具有一致性,从而减少了所需的PTV边界。