Yamamoto K, Shiroo M, Migita S
Science. 1986 Apr 11;232(4747):227-9. doi: 10.1126/science.3456645.
Serum amyloid A protein (SAA) is a precursor for a major component of amyloid fibrils, which, upon deposition, cause secondary amyloidosis in diseases such as rheumatoid arthritis. In mice, SAA is encoded by at least three genes, which show diverse expression during inflammation. Furthermore, in amyloidosis-resistant SJL mice, the gene expression for one SAA isotype, SAA2, is defective, although SAA2 gene expression is normal in amyloidosis-susceptible BALB/c mice. Because only SAA2-derived products deposit in mouse amyloid tissues, the resistance of SJL mice to amyloidosis seems to be due to defective SAA2 gene expression. Thus, the study emphasizes the importance of SAA gene structure in determining susceptibility to amyloidosis.
血清淀粉样蛋白A（SAA）是淀粉样原纤维主要成分的前体，沉积后会在类风湿性关节炎等疾病中引发继发性淀粉样变性。在小鼠中，SAA由至少三个基因编码，这些基因在炎症过程中表现出不同的表达。此外，在抗淀粉样变性的SJL小鼠中，一种SAA同种型SAA2的基因表达存在缺陷，尽管SAA2基因在易患淀粉样变性的BALB/c小鼠中表达正常。由于只有源自SAA2的产物沉积在小鼠淀粉样组织中，SJL小鼠对淀粉样变性的抗性似乎是由于SAA2基因表达缺陷所致。因此，该研究强调了SAA基因结构在决定对淀粉样变性易感性方面的重要性。
