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Preoperative Administration of Hycet Elixir Reduces Hospital Length of Stay After Pediatric Outpatient Adeno/Tonsillectomy.术前服用海赛特酏剂可缩短小儿门诊腺样体/扁桃体切除术后的住院时间。
Ochsner J. 2021 Fall;21(3):240-244. doi: 10.31486/toj.20.0101.
2
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Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstructive sleep apnea syndrome undergoing tonsillectomy and adenoidectomy.右美托咪定输注用于镇痛和预防阻塞性睡眠呼吸暂停综合征患儿扁桃体切除术和腺样体切除术术后苏醒期躁动。
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本文引用的文献

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Redefine statistical significance.重新定义统计学显著性。
Nat Hum Behav. 2018 Jan;2(1):6-10. doi: 10.1038/s41562-017-0189-z.
2
Statistical notes for clinical researchers: Risk difference, risk ratio, and odds ratio.临床研究人员的统计学笔记:风险差异、风险比和比值比。
Restor Dent Endod. 2017 Feb;42(1):72-76. doi: 10.5395/rde.2017.42.1.72. Epub 2017 Jan 9.
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Effects of intraoperative dexmedetomidine with intravenous anesthesia on postoperative emergence agitation/delirium in pediatric patients undergoing tonsillectomy with or without adenoidectomy: A CONSORT-prospective, randomized, controlled clinical trial.术中右美托咪定复合静脉麻醉对行扁桃体切除术(伴或不伴腺样体切除术)的小儿患者术后苏醒期躁动/谵妄的影响:一项遵循CONSORT标准的前瞻性随机对照临床试验。
Medicine (Baltimore). 2016 Dec;95(49):e5566. doi: 10.1097/MD.0000000000005566.
4
Emergence Delirium in Pediatric Anesthesia.小儿麻醉中的苏醒期谵妄
Paediatr Drugs. 2017 Feb;19(1):11-20. doi: 10.1007/s40272-016-0201-5.
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Effectiveness of preoperative intranasal dexmedetomidine compared with oral midazolam for the prevention of emergence delirium in pediatric patients undergoing general anesthesia: a systematic review protocol.术前经鼻给予右美托咪定与口服咪达唑仑预防小儿全身麻醉苏醒期谵妄的效果比较:一项系统评价方案
JBI Database System Rev Implement Rep. 2016 Aug;14(8):70-9. doi: 10.11124/JBISRIR-2016-003059.
6
Comparison of preoperative rectal paracetamol with paracetamol - diclofenac combination for postoperative analgesia in pediatric surgeries under general anesthesia.全身麻醉下小儿手术中术前直肠给予对乙酰氨基酚与对乙酰氨基酚 - 双氯芬酸联合用药用于术后镇痛的比较。
Anesth Essays Res. 2016 May-Aug;10(2):301-4. doi: 10.4103/0259-1162.171451.
7
Randomized controlled trial on preemptive analgesia for acute postoperative pain management in children.儿童术后急性疼痛管理中预防性镇痛的随机对照试验
Paediatr Anaesth. 2016 Apr;26(4):438-43. doi: 10.1111/pan.12864. Epub 2016 Feb 18.
8
Emergence delirium or pain after anaesthesia--how to distinguish between the two in young children: a retrospective analysis of observational studies.麻醉后出现谵妄或疼痛——如何在幼儿中区分两者:观察性研究的回顾性分析。
Br J Anaesth. 2016 Mar;116(3):377-83. doi: 10.1093/bja/aev552.
9
An investigation of the false discovery rate and the misinterpretation of p-values.对错误发现率和p值误读的调查。
R Soc Open Sci. 2014 Nov 19;1(3):140216. doi: 10.1098/rsos.140216. eCollection 2014 Nov.
10
Does the Preemptive Use of Oral Nonsteroidal Anti-inflammatory Drugs Reduce Postoperative Pain in Surgical Removal of Third Molars? A Meta-analysis of Randomized Clinical Trials.术前使用口服非甾体抗炎药能否减轻第三磨牙拔除术后疼痛?一项随机临床试验的荟萃分析。
Anesth Prog. 2015 Summer;62(2):57-63. doi: 10.2344/0003-3006-62.2.57.

术前服用海赛特酏剂可缩短小儿门诊腺样体/扁桃体切除术后的住院时间。

Preoperative Administration of Hycet Elixir Reduces Hospital Length of Stay After Pediatric Outpatient Adeno/Tonsillectomy.

作者信息

Salcedo Luis F, LeBlanc Brooke L, Martin Sarah M, Nossaman Bobby D

机构信息

Department of Anesthesiology, Ochsner Clinic Foundation, New Orleans, LA.

The University of Queensland Faculty of Medicine, Ochsner Clinical School, New Orleans, LA.

出版信息

Ochsner J. 2021 Fall;21(3):240-244. doi: 10.31486/toj.20.0101.

DOI:10.31486/toj.20.0101
PMID:34566503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8442212/
Abstract

Postoperative wound pain is commonly observed in the pediatric postanesthesia care unit (PACU) following tonsillectomy, adenoidectomy, and adenotonsillectomy (adeno/tonsillectomy), which contributes to increased medical care costs and delayed facility discharge. The purpose of this study was to review the benefits of preoperative administration of Hycet elixir (2.5 mg hydrocodone and 108 mg acetaminophen per 5 mL) in a pediatric population aged 1 to 9 years following adeno/tonsillectomy. Patient demographics, comorbidities, surgical and anesthetic times, need for postoperative rescue therapies, and PACU recovery and length of stay times were measured in pediatric patients who received preoperative administration of Hycet elixir (0.2 mg/kg hydrocodone) for adeno/tonsillectomy in an outpatient setting compared to a control group. The Hycet elixir group had significant reductions in PACU and hospital lengths of stay and significant reductions in the need for postoperative rescue analgesics. No significant differences were observed in emergence times or in the incidences of unplanned hospital admission between the control and Hycet elixir groups. These data show that the preoperative administration of Hycet elixir is well tolerated in the pediatric patient population undergoing adeno/tonsillectomy and appears to significantly reduce the need for postoperative rescue analgesics and postoperative care times. These data support the use of preoperative administration of Hycet elixir in this patient population.

摘要

扁桃体切除术、腺样体切除术及腺扁桃体切除术(腺/扁桃体切除术)后,小儿麻醉后护理单元(PACU)中常见术后伤口疼痛,这会导致医疗费用增加和出院延迟。本研究的目的是回顾术前给予海赛特酏剂(每5毫升含2.5毫克氢可酮和108毫克对乙酰氨基酚)对1至9岁接受腺/扁桃体切除术的儿科患者的益处。在门诊环境中,对接受术前给予海赛特酏剂(0.2毫克/千克氢可酮)进行腺/扁桃体切除术的儿科患者,与对照组相比,测量患者人口统计学、合并症、手术和麻醉时间、术后抢救治疗需求以及PACU恢复和住院时间。海赛特酏剂组的PACU和住院时间显著缩短,术后抢救镇痛药的需求也显著减少。对照组和海赛特酏剂组在苏醒时间或非计划住院发生率方面未观察到显著差异。这些数据表明,术前给予海赛特酏剂在接受腺/扁桃体切除术的儿科患者中耐受性良好,并且似乎显著减少了术后抢救镇痛药的需求和术后护理时间。这些数据支持在该患者群体中使用术前给予海赛特酏剂。