Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.
Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Front Endocrinol (Lausanne). 2021 Sep 10;12:715043. doi: 10.3389/fendo.2021.715043. eCollection 2021.
Anatomical proximity and functional correlations between the exocrine and endocrine pancreas warrant reciprocal effects between the two parts. Inflammatory diseases of the exocrine pancreas, such as acute or chronic pancreatitis, or the presence of cystic fibrosis disrupt endocrine function, resulting in diabetes of the exocrine pancreas. Although novel mechanisms are being increasingly identified, the intra- and intercellular pathways regulating exocrine-endocrine interactions are still not fully understood, making the development of new and more effective therapies difficult. Therefore, this review sought to accumulate current knowledge regarding the pathogenesis of diabetes in acute and chronic pancreatitis, as well as cystic fibrosis.
外分泌腺和内分泌腺在解剖位置上接近，功能上相互关联，这使得两者之间会产生相互影响。外分泌腺的炎症性疾病，如急性或慢性胰腺炎，或囊性纤维化的存在，会破坏内分泌功能，导致外分泌性糖尿病。尽管新的机制不断被发现，但调节外分泌-内分泌相互作用的细胞内和细胞间途径仍不完全清楚，这使得开发新的、更有效的治疗方法变得困难。因此，本综述旨在积累关于急性和慢性胰腺炎以及囊性纤维化中糖尿病发病机制的现有知识。
