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Editorial: Pathogens, Pathobionts, and Autoimmunity.

作者信息

Spatz Linda A, Silverman Gregg J, James Judith A

机构信息

Department of Molecular, Cellular, and Biomedical Sciences, CUNY School of Medicine, The City College of New York, New York, NY, United States.

Departments of Medicine and Pathology, New York University (NYU) Grossman School of Medicine, New York, NY, United States.

出版信息

Front Immunol. 2021 Sep 8;12:752980. doi: 10.3389/fimmu.2021.752980. eCollection 2021.

DOI:10.3389/fimmu.2021.752980
PMID:34567014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8456017/
Abstract
摘要

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Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at-risk individuals.EB 病毒血清再激活与高危人群系统性红斑狼疮转化的相关性。
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Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity.转录因子在疾病相关区域发挥作用，EBNA2 与自身免疫有关。
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Exhausted cytotoxic control of Epstein-Barr virus in human lupus.人类狼疮中 EB 病毒的细胞毒性控制耗竭。
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Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.人源 CD14dim 单核细胞通过 TLR7 和 TLR8 受体巡弋并感知核酸和病毒。
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Latent membrane protein 1, the EBV-encoded oncogenic mimic of CD40, accelerates autoimmunity in B6.Sle1 mice.潜伏膜蛋白1，即EB病毒编码的CD40致癌模拟物，可加速B6.Sle1小鼠的自身免疫反应。
J Immunol. 2010 Oct 1;185(7):4053-62. doi: 10.4049/jimmunol.0904065. Epub 2010 Sep 1.
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Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments.用EBNA-1片段免疫后兔子和小鼠中狼疮样自身抗体的产生
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EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN.EB病毒编码的RNA被RIG-I识别并激活信号传导以诱导I型干扰素。
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