Longman Randy S, Littman Dan R
Department of Medicine, Jill Roberts Institute for IBD Research, Weill Cornell Medical College, New York, New York, USA.
Curr Opin Rheumatol. 2015 Jul;27(4):381-7. doi: 10.1097/BOR.0000000000000190.
This review will highlight recent advances functionally linking the gut microbiome with mucosal and systemic immune cell activation underlying autoimmunity.
Dynamic interactions between the gut microbiome and environmental cues (including diet and medicines) shape the effector potential of the microbial organ. Key bacteria and viruses have emerged that, in defined microenvironments, play a critical role in regulating effector lymphocyte functions. The coordinated interactions between these different microbial kingdoms - including bacteria, helminths, and viruses (termed transkingdom interactions) - play a key role in shaping immunity. Emerging strategies to identify immunologically relevant microbes with the potential to regulate immune cell functions both at mucosal sites and systemically will likely define diagnostic and therapeutic targets.
The microbiome constitutes a critical microbial organ with coordinated interactions that shape host immunity.
本综述将重点介绍肠道微生物群与自身免疫基础上的黏膜和全身免疫细胞激活之间功能联系的最新进展。
肠道微生物群与环境线索(包括饮食和药物)之间的动态相互作用塑造了微生物器官的效应潜能。已发现关键细菌和病毒在特定微环境中对调节效应淋巴细胞功能起关键作用。这些不同微生物界(包括细菌、蠕虫和病毒,称为跨界相互作用)之间的协调相互作用在塑造免疫方面起关键作用。识别具有在黏膜部位和全身调节免疫细胞功能潜力的免疫相关微生物的新策略可能会确定诊断和治疗靶点。
微生物群构成一个具有协调相互作用的关键微生物器官,可塑造宿主免疫力。