Liu Qixin, Peng Ziheng, Shen Liangfang, Shen Lin
Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, China.
Front Oncol. 2021 Sep 8;11:737760. doi: 10.3389/fonc.2021.737760. eCollection 2021.
The prognostic and clinicopathological value of Ki-67 in melanoma is controversial. The purpose of this meta-analysis was to determine the prognostic role of Ki-67 in melanoma patients.
The PubMed, Cochrane Library, Web of Science, and Embase databases were searched systematically up to April 9, 2021. We calculated the pooled hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between Ki-67 overexpression and survival outcomes. We also calculated the combined odds ratios (ORs) and 95% CIs to determine the relationship between Ki-67 expression levels and clinicopathologic parameters. All data were statistically analyzed by Stata 11.0.
A total of 10 studies involving 929 patients were included in our meta-analysis. The pooled HR showed that Ki-67 overexpression was connected with poor overall survival rates (HR=2.92, 95% CI=2.17-3.91, p<0.000). However, there was no correlation between Ki-67 overexpression and the PFS (HR=0.999, 95% CI =0.958-1.041, P =0.958; I2 = 21.80%, P =0.258) or RFS (HR=1.14, 95% CI = 0.42-3.11, P =0.993; I2 = 85.00%, P =0.01) rates. Ki-67 expression levels were associated with tumor thickness, but not sex, location, ulceration or vascular invasion.
Ki-67 is a useful poor prognostic indicator for melanoma patients.
Ki-67在黑色素瘤中的预后及临床病理价值存在争议。本荟萃分析的目的是确定Ki-67在黑色素瘤患者中的预后作用。
系统检索截至2021年4月9日的PubMed、Cochrane图书馆、科学网和Embase数据库。我们计算了合并风险比（HRs）和95%置信区间（CIs），以确定Ki-67过表达与生存结果之间的关系。我们还计算了合并比值比（ORs）和95% CIs，以确定Ki-67表达水平与临床病理参数之间的关系。所有数据均采用Stata 11.0进行统计分析。
我们的荟萃分析共纳入10项研究，涉及929例患者。合并HR显示，Ki-67过表达与总体生存率低相关（HR=2.92，95% CI=2.17-3.91，p<0.000）。然而，Ki-67过表达与无进展生存期（HR=0.999，95% CI =0.958-1.041，P =0.958；I2 = 21.80%，P =0.258）或无复发生存率（HR=1.14，95% CI = 0.42-3.11，P =0.993；I2 = 85.00%，P =0.01）之间无相关性。Ki-67表达水平与肿瘤厚度相关，但与性别、位置、溃疡或血管侵犯无关。
Ki-67是黑色素瘤患者预后不良的一个有用指标。
