Katsuyama J, Papenhausen P R, Herz F, Gazivoda P, Hirano A, Koss L G
Cancer Genet Cytogenet. 1986 May;22(1):63-8. doi: 10.1016/0165-4608(86)90138-x.
Cytogenetic analyses of eight meningiomas grown in culture for 1 week are reported. Normal karyotypes were found in three cases and hypodiploidy in the remaining five. In the five hypodiploid meningiomas, one chromosome #22 was missing in four cases, and one case exhibited a 22q- deletion. In four of these five cases, chromosome #14 was either lost or altered. Chromosome #1 was lost or altered in three, and chromosome #6 in two. These findings lend further support for the association of total or partial loss of chromosome #22 in meningiomas and suggest the involvement of other chromosomes in the clonal evolution of these tumors.
报道了8例在培养中生长1周的脑膜瘤的细胞遗传学分析。3例发现核型正常，其余5例为亚二倍体。在这5例亚二倍体脑膜瘤中，4例缺失一条22号染色体，1例表现为22q-缺失。在这5例中的4例中，14号染色体丢失或改变。3例1号染色体丢失或改变，2例6号染色体丢失或改变。这些发现进一步支持了脑膜瘤中22号染色体全部或部分缺失的相关性，并提示其他染色体参与了这些肿瘤的克隆进化。
