Casalone R, Granata P, Simi P, Tarantino E, Butti G, Buonaguidi R, Faggionato F, Knerich R, Solero L
Cancer Genet Cytogenet. 1987 Jul;27(1):145-59. doi: 10.1016/0165-4608(87)90269-x.
Cytogenetic studies on 31 human meningiomas revealed clonal abnormalities in 14 of them. Monosomy 22 was present in three cases as the only abnormality, and in five it was associated with monosomy 18, monosomy 14, loss of X, loss of Y, and trisomy 20, respectively. We found a number of rearrangements involving chromosome #22: an i psu dic(22)(pter----q11::q11----pter) in two cases and a t(18;22)(q12;q11) in another case. Two cases showed a complex translocation involving #7 and #14: t(2;7;14)(q23;q36;q22) and t(1;7;14)(q25;q32;q22), respectively. Other clonal chromosome abnormalities were del(1p) (present in two cases); der(9)t(9;?)(q34;?); der(7)t(7;?)(q31;?); der(22)t(22;?)(q11;?); and a 9p+ chromosome. The relevance for the pathogenesis of human meningiomas of these chromosome anomalies is also discussed with reference to the previous literature. The possible involvement of recessive cancer genes present on the long arm of chromosome #22 is also discussed.
对31例人脑膜瘤进行的细胞遗传学研究显示，其中14例存在克隆性异常。22号染色体单体在3例中是唯一的异常情况，在另外5例中，它分别与18号染色体单体、14号染色体单体、X染色体缺失、Y染色体缺失和20号染色体三体相关。我们发现了一些涉及22号染色体的重排：2例存在i psu dic(22)(pter----q11::q11----pter)，另1例存在t(18;22)(q12;q11)。2例显示涉及7号和14号染色体的复杂易位，分别为t(2;7;14)(q23;q36;q22)和t(1;7;14)(q25;q32;q22)。其他克隆性染色体异常包括del(1p)（2例）；der(9)t(9;?)(q34;?)；der(7)t(7;?)(q31;?)；der(22)t(22;?)(q11;?)；以及一条9p+染色体。还结合先前的文献讨论了这些染色体异常对人脑膜瘤发病机制的相关性。还讨论了22号染色体长臂上存在的隐性癌基因可能的作用。
