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真核生物中U1 snRNP特异性蛋白U1C的系统发育比较与剪接分析

Phylogenetic Comparison and Splicing Analysis of the U1 snRNP-specific Protein U1C in Eukaryotes.

作者信息

Zhang Kai-Lu, Zhou Jian-Li, Yang Jing-Fang, Zhao Yu-Zhen, Das Debatosh, Hao Ge-Fei, Wu Caie, Zhang Jianhua, Zhu Fu-Yuan, Chen Mo-Xian, Zhou Shao-Ming

机构信息

Division of Gastroenterology, Shenzhen Children's Hospital, Shenzhen, China.

Co-Innovation Center for Sustainable Forestry in Southern China, College of Biology and the Environment, Nanjing Forestry University, Nanjing, China.

出版信息

Front Mol Biosci. 2021 Sep 9;8:696319. doi: 10.3389/fmolb.2021.696319. eCollection 2021.

DOI:10.3389/fmolb.2021.696319
PMID:34568424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8458698/
Abstract

As a pivotal regulator of 5' splice site recognition, U1 small nuclear ribonucleoprotein (U1 snRNP)-specific protein C (U1C) regulates pre-mRNA splicing by interacting with other components of the U1 snRNP complex. Previous studies have shown that U1 snRNP and its components are linked to a variety of diseases, including cancer. However, the phylogenetic relationships and expression profiles of U1C have not been studied systematically. To this end, we identified a total of 110 animal genes and compared them to homologues from yeast and plants. Bioinformatics analysis shows that the structure and function of U1C proteins is relatively conserved and is found in multiple copies in a few members of the U1C gene family. Furthermore, the expression patterns reveal that U1Cs have potential roles in cancer progression and human development. In summary, our study presents a comprehensive overview of the animal U1C gene family, which can provide fundamental data and potential cues for further research in deciphering the molecular function of this splicing regulator.

摘要

作为5'剪接位点识别的关键调节因子，U1小核核糖核蛋白（U1 snRNP）特异性蛋白C（U1C）通过与U1 snRNP复合物的其他成分相互作用来调节前体mRNA剪接。先前的研究表明，U1 snRNP及其成分与包括癌症在内的多种疾病有关。然而，尚未对U1C的系统发育关系和表达谱进行系统研究。为此，我们总共鉴定了110个动物基因，并将它们与酵母和植物中的同源物进行了比较。生物信息学分析表明，U1C蛋白的结构和功能相对保守，并且在U1C基因家族的一些成员中以多个拷贝存在。此外，表达模式表明U1C在癌症进展和人类发育中具有潜在作用。总之，我们的研究对动物U1C基因家族进行了全面概述，可为进一步研究该剪接调节因子的分子功能提供基础数据和潜在线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/c2b97b9a36ae/fmolb-08-696319-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/d23b7bec49e3/fmolb-08-696319-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/9d45edbcaeb8/fmolb-08-696319-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/2da995969b70/fmolb-08-696319-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/f5aeb0de7d51/fmolb-08-696319-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/c1f88a11a794/fmolb-08-696319-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/c2b97b9a36ae/fmolb-08-696319-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/d23b7bec49e3/fmolb-08-696319-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/9d45edbcaeb8/fmolb-08-696319-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/2da995969b70/fmolb-08-696319-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/f5aeb0de7d51/fmolb-08-696319-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/c1f88a11a794/fmolb-08-696319-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d91/8458698/c2b97b9a36ae/fmolb-08-696319-g006.jpg

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Dynamic regulation of Pep-induced immunity through post-translational control of defence transcript splicing.通过防御性转录本剪接的翻译后调控来实现 Pep 诱导免疫的动态调控。
Nat Plants. 2020 Aug;6(8):1008-1019. doi: 10.1038/s41477-020-0724-1. Epub 2020 Jul 20.
3
Phylogenetic comparison of 5' splice site determination in central spliceosomal proteins of the U1-70K gene family, in response to developmental cues and stress conditions.
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Full-Length Transcript-Based Proteogenomics of Rice Improves Its Genome and Proteome Annotation.基于全长转录本的水稻蛋白质组学研究提高了其基因组和蛋白质组注释。
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