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Measurement of Early and Late Repolarization Periods in Addition to QT Interval to Help Predict the Torsadogenic Risk of Donepezil Based on Reverse Translational Animal Research on Its Proarrhythmic Potential.

作者信息

Kambayashi Ryuichi, Goto Ai, Izumi-Nakaseko Hiroko, Matsumoto Akio, Sugiyama Atsushi

机构信息

Department of Pharmacology, Faculty of Medicine, Toho University Tokyo Japan.

Department of Aging Pharmacology, Faculty of Medicine, Toho University Tokyo Japan.

出版信息

Circ Rep. 2021 Aug 6;3(9):555-556. doi: 10.1253/circrep.CR-21-0061. eCollection 2021 Sep 10.

DOI:10.1253/circrep.CR-21-0061
PMID:34568635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8423611/
Abstract
摘要

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1
Measurement of Early and Late Repolarization Periods in Addition to QT Interval to Help Predict the Torsadogenic Risk of Donepezil Based on Reverse Translational Animal Research on Its Proarrhythmic Potential.基于对多奈哌齐致心律失常潜力的反向转化动物研究，除测量QT间期外，还测量早期和晚期复极期，以帮助预测多奈哌齐的致尖端扭转型室速风险。
Circ Rep. 2021 Aug 6;3(9):555-556. doi: 10.1253/circrep.CR-21-0061. eCollection 2021 Sep 10.
2
Measurement of Early and Late Repolarization Periods in Addition to QT Interval to Help Predict the Torsadogenic Risk of Donepezil Based on Reverse Translational Animal Research on Its Proarrhythmic Potential　- Reply.基于对多奈哌齐促心律失常潜力的反向转化动物研究，除测量QT间期外，还测量早期和晚期复极期以帮助预测多奈哌齐的致扭转型室性心动过速风险——回复
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3
Nonclinical proarrhythmia models: predicting Torsades de Pointes.非临床致心律失常模型：预测尖端扭转型室速
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本文引用的文献

1
Effect of QT Prolongation in Patients Taking Cholinesterase Inhibitors (Donepezil) for Alzheimer's Disease.服用胆碱酯酶抑制剂（多奈哌齐）治疗阿尔茨海默病患者的QT间期延长效应。
Circ Rep. 2021 Feb 26;3(3):115-121. doi: 10.1253/circrep.CR-20-0115.
2
Cardiohemodynamic and Arrhythmogenic Effects of the Anti-Atrial Fibrillatory Compound Vanoxerine in Halothane-Anesthetized Dogs.抗心房颤动化合物瓦诺昔林对氟烷麻醉犬的心脏血流动力学和致心律失常作用
Cardiovasc Toxicol. 2021 Mar;21(3):206-215. doi: 10.1007/s12012-020-09612-3. Epub 2020 Oct 19.
3
Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones.采用氟烷麻醉的完整狗和清醒慢性房室传导阻滞狗分析多奈哌齐的电药理学和致心律失常作用。
Naunyn Schmiedebergs Arch Pharmacol. 2021 Apr;394(4):581-589. doi: 10.1007/s00210-020-01997-w. Epub 2020 Oct 16.
4
Donepezil-induced QTc prolongation: A case report.多奈哌齐诱发的QTc间期延长：一例报告。
Ment Health Clin. 2019 May 10;9(3):128-132. doi: 10.9740/mhc.2019.05.128. eCollection 2019 May.
5
Donepezil-induced torsades de pointes without QT prolongation.多奈哌齐诱发的尖端扭转型室速，无QT间期延长。
J Cardiol Cases. 2013 Jun 25;8(2):e69-e71. doi: 10.1016/j.jccase.2013.05.004. eCollection 2013 Aug.
6
A case of donepezil-related torsades de pointes.一例与多奈哌齐相关的尖端扭转型室性心动过速。
BMJ Case Rep. 2015 Oct 5;2015:bcr2015211900. doi: 10.1136/bcr-2015-211900.
7
Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.心电图上鉴别药物诱导的多通道阻滞：多非利特、奎尼丁、雷诺嗪和维拉帕米的随机研究。
Clin Pharmacol Ther. 2014 Nov;96(5):549-58. doi: 10.1038/clpt.2014.155. Epub 2014 Jul 23.
8
Torsades de Pointes with QT prolongation related to donepezil use.多形性室性心动过速伴 QT 延长与多奈哌齐的使用有关。
J Cardiol. 2009 Dec;54(3):507-11. doi: 10.1016/j.jjcc.2009.03.011. Epub 2009 May 7.
9
Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes.多奈哌齐引起的心律不良反应：2例房室传导阻滞和尖端扭转型室速报告
Intern Med. 2009;48(14):1219-23. doi: 10.2169/internalmedicine.48.2181. Epub 2009 Jul 15.
10
Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts.用于预测心脏重构患者药物诱导尖端扭转型室速的敏感且可靠的体内致心律失常动物模型。
Br J Pharmacol. 2008 Aug;154(7):1528-37. doi: 10.1038/bjp.2008.240. Epub 2008 Jun 16.