Measurement of Early and Late Repolarization Periods in Addition to QT Interval to Help Predict the Torsadogenic Risk of Donepezil Based on Reverse Translational Animal Research on Its Proarrhythmic Potential - Reply.
作者信息
Kuwahata So, Motoya Toshiro, Takenaka Toshihiro
机构信息
Department of Internal and Cardiovascular Medicine, Tarumizu Chuo Hospital, Tarumizu Municipal Medical Center Tarumizu Japan.
Pharmaceutical Department, Tarumizu Chuo Hospital, Tarumizu Municipal Medical Center Tarumizu Japan.
出版信息
Circ Rep. 2021 Aug 6;3(9):556-557. doi: 10.1253/circrep.CR-21-0086. eCollection 2021 Sep 10.
Abstract
摘要
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Measurement of Early and Late Repolarization Periods in Addition to QT Interval to Help Predict the Torsadogenic Risk of Donepezil Based on Reverse Translational Animal Research on Its Proarrhythmic Potential - Reply.基于对多奈哌齐促心律失常潜力的反向转化动物研究，除测量QT间期外，还测量早期和晚期复极期以帮助预测多奈哌齐的致扭转型室性心动过速风险——回复
Circ Rep. 2021 Aug 6;3(9):556-557. doi: 10.1253/circrep.CR-21-0086. eCollection 2021 Sep 10.
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Measurement of Early and Late Repolarization Periods in Addition to QT Interval to Help Predict the Torsadogenic Risk of Donepezil Based on Reverse Translational Animal Research on Its Proarrhythmic Potential.基于对多奈哌齐致心律失常潜力的反向转化动物研究，除测量QT间期外，还测量早期和晚期复极期，以帮助预测多奈哌齐的致尖端扭转型室速风险。
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本文引用的文献
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Effect of QT Prolongation in Patients Taking Cholinesterase Inhibitors (Donepezil) for Alzheimer's Disease.服用胆碱酯酶抑制剂（多奈哌齐）治疗阿尔茨海默病患者的QT间期延长效应。
Circ Rep. 2021 Feb 26;3(3):115-121. doi: 10.1253/circrep.CR-20-0115.
2
Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones.采用氟烷麻醉的完整狗和清醒慢性房室传导阻滞狗分析多奈哌齐的电药理学和致心律失常作用。
Naunyn Schmiedebergs Arch Pharmacol. 2021 Apr;394(4):581-589. doi: 10.1007/s00210-020-01997-w. Epub 2020 Oct 16.
3
The relationship between myocardial fibrosis detected by cardiac magnetic resonance and Tp-e interval, 5-year sudden cardiac death risk score in hypertrophic cardiomyopathy patients.心脏磁共振检测的心肌纤维化与肥厚型心肌病患者Tp-e间期、5年心源性猝死风险评分之间的关系。
Ann Noninvasive Electrocardiol. 2019 Sep;24(5):e12672. doi: 10.1111/anec.12672. Epub 2019 Jun 1.
4
Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk.用于评估药物诱导的心律失常风险的J峰和T峰-终末间期的自动算法
PLoS One. 2016 Dec 30;11(12):e0166925. doi: 10.1371/journal.pone.0166925. eCollection 2016.
5
Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death.静息心电图上 T 峰值至 T 末间期延长与心源性猝死风险增加相关。
Circ Arrhythm Electrophysiol. 2011 Aug;4(4):441-7. doi: 10.1161/CIRCEP.110.960658. Epub 2011 May 18.
6
Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome.Brugada综合征患者中，T波峰末间期和T波峰末间期离散度作为室性心动过速/心室颤动的危险因素。
J Am Coll Cardiol. 2006 May 2;47(9):1828-34. doi: 10.1016/j.jacc.2005.12.049. Epub 2006 Apr 17.
7
T-peak to T-end interval may be a better predictor of high-risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin I mutation than QT dispersion.与QT离散度相比，T峰至T末间期可能是预测与心肌肌钙蛋白I突变相关的肥厚型心肌病高危患者的更好指标。
Clin Cardiol. 2002 Jul;25(7):335-9. doi: 10.1002/clc.4950250706.
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Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome.正常T波的细胞基础及长QT综合征的心电图表现
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