补充洋蓟叶提取物或饮用洋蓟汁对血脂水平的影响：一项随机对照试验的系统评价和剂量反应荟萃分析
Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose-response meta-analysis of randomized controlled trials.
作者信息
Shahinfar Hossein, Bazshahi Elham, Amini Mohammad Reza, Payandeh Nastaran, Pourreza Sanaz, Noruzi Zahra, Shab-Bidar Sakineh
机构信息
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Faculty of Public Health, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Phytother Res. 2021 Dec;35(12):6607-6623. doi: 10.1002/ptr.7247. Epub 2021 Sep 27.
Accumulating evidence regarding the effect of artichoke on lipid profile is equivocal. We updated a previous meta-analysis on the effect of artichoke extract supplementation on lipid profile and performed dose-response analysis. We searched PubMed, Scopus, Web of Science, and Cochrane Library from inception to June 2021 using relevant keywords. Papers from identified articles were collected. Two researchers rated the certainty in the estimates using the GRADE approach. Combining 15 effect sizes from 14 studies based on the random-effects analysis, we found that artichoke significantly reduced TG (weighed mean difference [WMD]: -17.01 mg/dl, 95% CI: -23.88, -10.13, p = .011), TC (WMD: -17.01 mg/dl, 95% CI: -23.88, -10.13, p < .001), and LDL-C (WMD: -17.48 mg/dl, 95%CI: -25.44, -9.53, p < .001). No significant effect of artichoke on HDL-C level was detected (WMD: 0.78 mg/dl, 95%CI: -0.93, 2.49, p = .371). Combining the two effect sizes revealed that artichoke juice supplementation significantly reduced TG (WMD: -3.34 mg/dl, 95%CI: -5.51, -1.17, p = .003), TC (WMD: -18.04 mg/dl, 95%CI: -20.30, -15.78, p < .001), LDL-C (WMD: -1.75 mg/dl, 95%CI: -3.02, -0.48, p = .007), and HDL-C levels (WMD: -4.21 mg/dl, 95%CI: -5.49, -2.93, p < .001). In conclusion, we found that artichoke supplementation may favor CVD prevention by acting in improving the lipid profile.
关于洋蓟对血脂影响的证据越来越多，但尚无定论。我们更新了之前关于补充洋蓟提取物对血脂影响的荟萃分析，并进行了剂量反应分析。我们使用相关关键词在PubMed、Scopus、Web of Science和Cochrane图书馆中检索了从创刊到2021年6月的文献。收集了已识别文章中的论文。两名研究人员使用GRADE方法对估计的确定性进行了评级。基于随机效应分析，结合14项研究中的15个效应量，我们发现洋蓟显著降低了甘油三酯（加权平均差[WMD]：-17.01mg/dl，95%置信区间：-23.88，-10.13，p = 0.011）、总胆固醇（WMD：-17.01mg/dl，95%置信区间：-23.88，-10.13，p < 0.001）和低密度脂蛋白胆固醇（WMD：-17.48mg/dl，95%置信区间：-25.44，-9.53，p < 0.001）。未检测到洋蓟对高密度脂蛋白胆固醇水平有显著影响（WMD：0.78mg/dl，95%置信区间：-0.93，2.49，p = 0.371）。综合两个效应量显示，补充洋蓟汁显著降低了甘油三酯（WMD：-3.34mg/dl，95%置信区间：-5.51，-1.17，p = 0.003）、总胆固醇（WMD：-18.04mg/dl，95%置信区间：-20.30，-15.78，p < 0.001）、低密度脂蛋白胆固醇（WMD：-1.75mg/dl，95%置信区间：-3.02，-0.48，p = 0.007）和高密度脂蛋白胆固醇水平（WMD：-4.21mg/dl，95%置信区间：-5.49，-2.93，p < 0.001）。总之，我们发现补充洋蓟可能通过改善血脂状况有助于预防心血管疾病。
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