富含单不饱和脂肪酸的食物对血脂水平的影响：随机对照喂养试验的荟萃分析。

The Effect of MUFA-Rich Food on Lipid Profile: A Meta-Analysis of Randomized and Controlled-Feeding Trials.

作者信息

Cao Xinyi, Xia Jiayue, Zhou Yuhao, Wang Yuanyuan, Xia Hui, Wang Shaokang, Liao Wang, Sun Guiju

机构信息

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.

Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

出版信息

Foods. 2022 Jul 5;11(13):1982. doi: 10.3390/foods11131982.

Since the effects of mono-unsaturated fatty acids (MUFA) on lipid profile are still controversial, a meta-analysis of randomized controlled trials was conducted in the present study to assess the effect of MUFA-rich food on lipid profiles. The study was designed, conducted, and reported according to the guidelines of the 2020 preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. A systematic and comprehensive search was performed in several databases from inception up to 30 January 2022. The results showed that the intake of edible oil-derived MUFA (EDM) could increase the blood HDL-C level (mean difference = 0.08; 95%CI: -0.01, 0.17, = 0.03), but did not affect the level of TC, TG, or LDL-C. Moreover, the consumption of other food-derived MUFA (ODM) significantly decreased TG concentration (mean difference = -0.35; 95%CI: -0.61, -0.09, = 0.01)), but did not affect the level of TC, LDL-C, or HDL-C. Findings from this study suggest that MUFA-rich food might be beneficial to modulate the blood lipid profile.

由于单不饱和脂肪酸（MUFA）对血脂的影响仍存在争议，本研究进行了一项随机对照试验的荟萃分析，以评估富含MUFA的食物对血脂的影响。该研究是根据2020年系统评价和荟萃分析首选报告项目（PRISMA）声明的指南进行设计、实施和报告的。从数据库建立至2022年1月30日进行了系统全面的检索。结果显示，食用植物油衍生的MUFA（EDM）可提高血液高密度脂蛋白胆固醇（HDL-C）水平（平均差异=0.08；95%置信区间：-0.01，0.17，P=0.03），但不影响总胆固醇（TC）、甘油三酯（TG）或低密度脂蛋白胆固醇（LDL-C）水平。此外，食用其他食物衍生的MUFA（ODM）可显著降低TG浓度（平均差异=-0.35；95%置信区间：-0.61，-0.09，P=0.01），但不影响TC、LDL-C或HDL-C水平。本研究结果表明，富含MUFA的食物可能有助于调节血脂。