Optom Vis Sci. 2021 Sep 1;98(9):1104-1112. doi: 10.1097/OPX.0000000000001774.
Commercially available platforms show good agreement in clinical outcomes for retinal vessel caliber measurements, despite differing absolute values. Tighter agreement is observed when right and left eye data are averaged, suggesting an approach suitable for clinical practice.
The purpose of this study was to compare the retinal vessel caliber measurements generated by different commercially available platforms and their associations with systemic blood pressure and age.
A total of 209 participants were recruited from a UK optometric practice. After a routine eye examination, participants had disc-centered retinal photographs and systemic blood pressure taken. Retinal vessel calibers (central retinal artery equivalent, central retinal vein equivalent, and arteriovenous ratio) were calculated using both MONA REVA and VesselMap.
An inverse Pearson correlation was observed between central retinal artery equivalent and mean arterial blood pressure on both platforms (r = -0.275 [P ≤ .001] and r = -0.388 [P ≤ .001] for MONA REVA and VesselMap, respectively); this correlation was also observed with arteriovenous ratio and blood pressure. An inverse correlation was observed between central retinal artery equivalent and age (r = -0.362 [P ≤ .001] and r = -0.404 [P ≤ .001] for MONA REVA and VesselMap, respectively); this was also seen between central retinal vein equivalent and age (r = -0.322 [P ≤ .001] and r = -0.369 [P ≤ .001]). Arteriovenous ratio remained independent from age for both platforms. Bland-Altman plots demonstrated good agreement between the platforms for all three variables.
Although absolute caliber measurements differed between the platforms, the correlations observed were of similar magnitudes, with good agreement between the two platforms. Tighter spaced limits of agreement were observed when right and left eye data were averaged for each subject. In the absence of localized ocular pathology, this approach should be used.
尽管商业上可用的平台在视网膜血管口径测量的临床结果上显示出良好的一致性，但绝对数值存在差异。当左右眼数据平均时，观察到更紧密的一致性，这表明了一种适合临床实践的方法。
本研究旨在比较不同商业上可用的平台生成的视网膜血管口径测量值及其与系统性血压和年龄的关系。
共从英国验光实践中招募了 209 名参与者。在常规眼部检查后，对参与者进行了视盘中心的视网膜照片和全身血压检查。使用 MONA REVA 和 VesselMap 计算视网膜血管口径（中央视网膜动脉当量、中央视网膜静脉当量和动静脉比）。
在两个平台上，中央视网膜动脉当量与平均动脉血压之间都观察到了反向皮尔逊相关性（MONA REVA 和 VesselMap 分别为 r = -0.275 [P ≤.001] 和 r = -0.388 [P ≤.001]）；这种相关性也存在于动静脉比和血压之间。中央视网膜动脉当量与年龄之间观察到了负相关（MONA REVA 和 VesselMap 分别为 r = -0.362 [P ≤.001] 和 r = -0.404 [P ≤.001]）；中央视网膜静脉当量与年龄之间也存在负相关（r = -0.322 [P ≤.001] 和 r = -0.369 [P ≤.001]）。两个平台上的动静脉比都独立于年龄。Bland-Altman 图表明两个平台之间的所有三个变量都具有良好的一致性。当每个受试者的左右眼数据平均时，观察到更紧密的区间一致性。在没有局部眼部病变的情况下，应使用这种方法。
