Department of Family and Community Medicine, Penn State Health Milton S. Hershey, Hershey, PA, USA.
Penn State College of Medicine, Hershey, PA 17033, USA.
Mil Med. 2022 Oct 29;187(11-12):e1480-e1482. doi: 10.1093/milmed/usab314.
Coronavirus disease (COVID) toes are pernio-like skin lesions associated with severe acute respiratory syndrome coronavirus 2. We observed pernio-like skin findings presenting after a Pfizer BioNTech vaccine, which significantly worsened after an infusion of rituximab. This suggests that the mechanism for COVID toes is interferon activation. Military providers may avoid unnecessary referrals for this self-limiting condition by anticipating this adverse effect.
新型冠状病毒病（COVID）的脚趾类似于冻疮样皮肤病变，与严重急性呼吸综合征冠状病毒 2 有关。我们观察到 Pfizer BioNTech 疫苗接种后出现冻疮样皮肤表现，在用利妥昔单抗输注后明显恶化。这表明 COVID 脚趾的机制是干扰素激活。军事医疗提供者可以通过预测这种不良反应来避免为这种自限性疾病进行不必要的转诊。
