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辉瑞-生物科技 COVID-19 疫苗(BNT162b2,即 托珠单抗)接种后心肌炎引起的室性心动过速。

Ventricular tachycardia from myocarditis following COVID-19 vaccination with tozinameran (BNT162b2, Pfizer-BioNTech).

机构信息

Department of Cardiology, National University Heart Centre, Singapore, Singapore.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

出版信息

Pacing Clin Electrophysiol. 2022 Sep;45(9):1097-1100. doi: 10.1111/pace.14486. Epub 2022 Apr 4.

Abstract

To combat the coronavirus disease 2019 (COVID-19) pandemic, many countries have started population vaccination programs using messenger ribonucleic acid (mRNA) vaccines. With the widespread use of such vaccines, reports are emerging worldwide, of the vaccine's association with the development of myocarditis. Younger men are more likely to develop postvaccine myocarditis, which usually presents as self-limiting chest pain within a week after the second dose. We present a case of myocarditis following vaccination with tozinameran (BNT162b2, Pfizer-BioNTech), which presented late, with ventricular tachycardia (VT) reduced left ventricular ejection fraction (LVEF).

摘要

为了应对 2019 年冠状病毒病(COVID-19)大流行,许多国家已经启动了使用信使核糖核酸(mRNA)疫苗的人群接种计划。随着这些疫苗的广泛使用,世界各地都有报告称疫苗与心肌炎的发生有关。年轻男性更有可能在接种第二剂疫苗后一周内发生疫苗相关心肌炎,通常表现为自限性胸痛。我们报告了一例接种托珠单抗(BNT162b2,辉瑞-生物科技)后发生的心肌炎,其表现较晚,出现室性心动过速(VT)和左心室射血分数(LVEF)降低。

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