Slater L M, Sweet P, Stupecky M, Gupta S
J Clin Invest. 1986 Apr;77(4):1405-8. doi: 10.1172/JCI112450.
The development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has little effect on vincristine or daunorubicin activity in drug-sensitive parental leukemia and corrects daunorubicin resistance without altering cellular daunorubicin accumulation.
肿瘤细胞产生耐药性是治愈人类恶性肿瘤的主要障碍。环孢素A(CsA)可完全逆转人T细胞急性淋巴细胞白血病多药耐药亚系对长春新碱的原发性耐药以及对柔红霉素的交叉耐药。该亚系对长春新碱的耐药性超过50倍,对柔红霉素的耐药性为5倍。CsA对药物敏感的亲代白血病细胞中长春新碱或柔红霉素的活性几乎没有影响,并且在不改变细胞内柔红霉素蓄积的情况下纠正柔红霉素耐药。