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免疫功能正常患者的蛎壳样结痂性疥疮伴骨质溶解的不常见表现。

Unusual presentation of crusted scabies with osteolysis in immunocompetent.

机构信息

Department of Dermatology, Seth G.S. Medical College and K.E.M Hospital, Parel, Mumbai, India.

出版信息

Australas J Dermatol. 2021 Nov;62(4):e563-e567. doi: 10.1111/ajd.13726. Epub 2021 Sep 27.

Abstract

BACKGROUND

Crusted scabies results from a failure of the host immune response to control the proliferation of the scabies mite in the skin, with resulting hyperinfestation and a concomitant inflammatory and hyper-keratotic reaction. However, it has also been recognised in people with no evident immunological deficit.

CASE HISTORY

We present a case report of apparently immunocompetent 16-year-old female presenting with multiple hyperkeratotic vegetating plaques over limbs, excoriated papules over trunk with minimal itching since 2 years without any positive family history. The microscopic examination of the skin scales with potassium hydroxide demonstrated numerous scabies mites and eggs. Histopathology showed hyperkeratosis with multiple mites in stratum corneum. Numerous mites were seen on biopsy of lesion. X-ray showed osteolysis of distal phalanges secondary to chronic pressure. Repeated topical treatments with permethrin and oral ivermectin led to the considerable resolution of her lesions.

CONCLUSION

We present a rare case of crusted scabies with osteolysis in an immunocompetent female.

摘要

背景

结痂性疥疮是由于宿主免疫反应未能控制疥螨在皮肤中的增殖而导致的,结果是过度感染和伴随的炎症和过度角化反应。然而,它也在没有明显免疫缺陷的人群中被认识到。

病例报告

我们报告了一例明显免疫功能正常的 16 岁女性,她的四肢有多个角化过度的肉芽状斑块,躯干有抓痕性丘疹,几乎没有瘙痒,已有 2 年,且无阳性家族史。皮肤鳞片的氢氧化钾显微镜检查显示有大量疥螨和卵。组织病理学显示角化过度,角质层有多个螨虫。病变活检可见大量螨虫。X 射线显示慢性压迫导致远端指骨骨质溶解。反复使用扑灭司林和口服伊维菌素进行局部治疗后,她的皮损得到了很大程度的缓解。

结论

我们报告了一例免疫功能正常的女性罕见的伴有骨质溶解的结痂性疥疮病例。

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