IEEE Trans Nanobioscience. 2022 Apr;21(2):312-319. doi: 10.1109/TNB.2021.3115906. Epub 2022 Mar 31.
The present work exhibits a novel design of surface plasmon resonance (SPR) biosensor, which comprises CaF prism, TiO, metal (Ag/Au), PtSe, 2D materials (graphene/transition metal dichalcogenides (MoS/WS)) and sensing medium, for point-of-care detection of various stages of malaria diseases. The transfer matrix method (TMM) is employed to examine the angular reflectivity of the proposed structure after judiciously optimizing the layer thicknesses and layer numbers. Phase interrogation technique is utilised to validate the position of occurrence of resonance angles. Additionally, the proposed SPR structure is designed using COMSOL Multiphysics, to assay the electric field intensity and electric field enhancement factor near the edge of 2D material-sensing layer interface. Simulation upshots revealed that the use of new class of 2D materials catapult the sensor performance to a new height compared to the traditional SPR configuration. A maximum sensitivity of 240.10°/RIU, quality factor of 78.46 RIU and detection accuracy of 1.99 is attained for Ag-based SPR configuration with bilayer of WS. Sensing parameters are compared with previously reported works to prove the superiority of the present research. Moreover, the real-time and label-free detection of malaria diseases makes the suggested sensor worth to fabricate as a SPR chip with the recent nanofabrication technologies.
本工作展示了一种新颖的表面等离子体共振（SPR）生物传感器设计，该传感器由 CaF 棱镜、TiO、金属（Ag/Au）、PtSe、二维材料（石墨烯/过渡金属二卤化物（MoS/WS））和传感介质组成，用于即时检测疟疾疾病的各个阶段。转移矩阵法（TMM）用于在合理优化层厚度和层数后检查所提出结构的角反射率。相位询问技术用于验证共振角的位置。此外，使用 COMSOL Multiphysics 设计了所提出的 SPR 结构，以评估二维材料传感层界面边缘附近的电场强度和电场增强因子。模拟结果表明，与传统的 SPR 配置相比，使用新型二维材料将传感器性能提升到了一个新的高度。对于具有双层 WS 的基于 Ag 的 SPR 配置，实现了 240.10°/RIU 的最大灵敏度、78.46 RIU 的品质因数和 1.99 的检测精度。与之前报道的工作相比，对传感参数进行了比较，以证明本研究的优越性。此外，疟疾疾病的实时和无标记检测使得建议的传感器值得使用最近的纳米制造技术制造 SPR 芯片。
