Basak Chaity, Islam Md Saiful, Hosain Md Kamal, Kouzani Abbas Z
Department of Electronics & Telecommunication Engineering, Rajshahi University of Engineering & Technology, Rajshahi, 6204, Bangladesh.
School of Engineering, Military Technological College, Muscat, Oman.
Heliyon. 2024 Sep 28;10(19):e38499. doi: 10.1016/j.heliyon.2024.e38499. eCollection 2024 Oct 15.
This paper presents the design and simulation of a surface plasmon resonance (SPR) biosensor using a Platinum diselenide (PtSe) and Blue Phosphorus/tungsten disulfide (BlueP/WS) heterostructure for biosensing protocols. The simulation is done by using a finite element method (FEM) based COMSOL Multiphysics software. The performance of the SPR biosensor is then optimized for obtaining maximum sensitivity, quality factor, detection accuracy, and low limit of detection (LOD). The SPR biosensor demonstrates a maximum sensitivity of 234 deg/RIU, suggesting its ability to detect minute refractive index changes with remarkable precision. Furthermore, a quality factor of 390 RIU demonstrates the biosensor's capacity to detect tiny fluctuations in target analyte concentration. The achieved detection accuracy of 7.8 deg presents the biosensor's ability to detect target biomolecule solutions in the desired RI range. The remarkably low LOD of 4.26 × 10 ensures early and accurate detection. The significance of this research lies in five layered hetero-structure based combinations of BK7 prism, gold, PtSe, BlueP/WS and sensing medium respectively. The introduction of transition metal dichalcogenides (TMDC) material of PtSe with a hybrid 2D nanomaterials heterostructure of BlueP and TMDCs offers a rapid, sensitive, label-free and reliable platform for early detection. Additionally, the FEM method allows for the investigation of physical phenomena as part of the work. In summary, the proposed senor outcomes effectively demonstrate the speedy capability of detecting any pathogens or analytes in the RI range of 1.330-1.350 with remarkable sensitivity and accuracy. The rapid detection without giving false results is the benefit of the proposed sensor structure.
本文介绍了一种用于生物传感协议的表面等离子体共振（SPR）生物传感器的设计与模拟，该传感器使用二硒化铂（PtSe）和蓝磷/二硫化钨（BlueP/WS）异质结构。模拟通过基于有限元方法（FEM）的COMSOL Multiphysics软件完成。然后对SPR生物传感器的性能进行优化，以获得最大灵敏度、品质因数、检测精度和低检测限（LOD）。该SPR生物传感器表现出234度/RIU的最大灵敏度，表明其能够以极高的精度检测微小的折射率变化。此外，390 RIU的品质因数证明了该生物传感器检测目标分析物浓度微小波动的能力。实现的7.8度检测精度表明该生物传感器能够在所需的RI范围内检测目标生物分子溶液。4.26×10的极低检测限确保了早期准确检测。本研究的意义在于分别基于BK7棱镜、金、PtSe、BlueP/WS和传感介质的五层异质结构组合。引入具有BlueP和过渡金属二卤化物（TMDC）混合二维纳米材料异质结构的PtSe过渡金属二卤化物（TMDC）材料，为早期检测提供了一个快速、灵敏、无标记且可靠的平台。此外，有限元方法允许作为工作的一部分研究物理现象。总之，所提出的传感器结果有效地证明了其能够以显著的灵敏度和准确性在1.330 - 1.350的RI范围内快速检测任何病原体或分析物。所提出的传感器结构的优点是能够快速检测且不产生错误结果。
