Kuthethur Raviprasad, Prasad Keshava, Chakrabarty Sanjiban, Kabekkodu Shama Prasada, Singh Keshav K, Thangaraj Kumarasamy, Satyamoorthy Kapaettu
Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, India.
Department of Genetics, School of Medicine, The University of Alabama at Birmingham, Kaul Genetics Building, Rm. 620, 720 20th St. South, Birmingham, AL, 35294, United States.
Mitochondrion. 2021 Nov;61:62-68. doi: 10.1016/j.mito.2021.09.008. Epub 2021 Sep 24.
Current knowledge of mitochondrial biology and function has provided tools and technologies that helped a better understanding of the molecular etiology of complex mitochondrial disorders. Dual genetic control of this subcellular organelle function regulates various signaling mechanisms which are essential for metabolism, bioenergetics, fatty acid biosynthesis, and DNA replication & repair. Understanding nuclear mitochondrial crosstalk through advanced genomics as well as clinical perspectives is the overall basis of mitochondrial research and medicine, also the sole objective of Society for Mitochondrial Medicine and Research (SMRM) - India. The eighth virtual international conference on 'Advances in Mitochondrial Medicine and Translational Research' was organized at the Manipal School of Life Sciences, MAHE, Manipal, India, during 6 - 7 November 2020. The aim of the virtual conference was to highlight the recent advances and future perspectives that represent comprehensive clinical and fundamental research interests in the area of mitochondrial biology of human diseases. To systematically present the various findings in mitochondrial biology, the meeting was themed with specific aspects comprising (a) mitochondrial disorders: clinical & genomic perspectives, (b) mitochondria in cancer, (c) mitochondrial metabolism & disorders, and (d) mitochondrial diseases & therapy. This report provides an overview of the recent advancements in the area of mitochondrial biology and medicine that was discussed at the conference.
目前对线粒体生物学和功能的认识提供了工具和技术，有助于更好地理解复杂线粒体疾病的分子病因。这种亚细胞器功能的双重遗传控制调节着各种信号传导机制，这些机制对新陈代谢、生物能量学、脂肪酸生物合成以及DNA复制和修复至关重要。通过先进的基因组学以及临床视角来理解核线粒体间的相互作用，是线粒体研究和医学的总体基础，也是印度线粒体医学与研究协会（SMRM）的唯一目标。2020年11月6日至7日，第八届“线粒体医学与转化研究进展”虚拟国际会议在印度马尼帕尔马尼帕尔高等教育学院生命科学学院举行。此次虚拟会议的目的是突出近期进展以及未来展望，这些进展和展望代表了人类疾病线粒体生物学领域全面的临床和基础研究兴趣。为了系统展示线粒体生物学的各种研究成果，会议围绕特定主题展开，包括（a）线粒体疾病：临床与基因组视角，（b）癌症中的线粒体，（c）线粒体代谢与疾病，以及（d）线粒体疾病与治疗。本报告概述了会议上讨论的线粒体生物学和医学领域的近期进展。
