Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
Division of Biochemistry, Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Biochem Genet. 2024 Apr;62(2):575-593. doi: 10.1007/s10528-023-10490-x. Epub 2023 Aug 26.
The coenzyme ubiquinone-10 (CoQ10) is not only an important part of the electron transport chain of the mitochondrial inner membrane but also has complex biological functions beyond mitochondrial respiration. It is a natural nutrient that is not only produced by the body but is also found in foods, such as meat, eggs, fish, and vegetable oils. Because some types of cancer reduce CoQ10 blood levels, the use of CoQ10 supplements is recommended for the treatment of cancer patients. The anti-cancer effects of CoQ10 supplementation have been reported in several cancers, including colon and breast cancer. CoQ10 scavenges free radicals to reduce oxidative stress and minimize tissue damage. CoQ10 protects the body from damage caused by chemotherapy drugs by reducing the production of inflammatory cytokines and other inflammatory factors. Recent studies suggest that CoQ10 may be a supplement to pharmacotherapy for hepatocellular carcinoma. This article examines the effects of CoQ10 in hepatocellular carcinoma.
辅酶泛醌-10（CoQ10）不仅是线粒体内膜电子传递链的重要组成部分，而且具有超越线粒体呼吸的复杂生物学功能。它是一种天然营养素，不仅由人体产生，而且存在于肉类、鸡蛋、鱼类和植物油等食物中。由于某些类型的癌症会降低 CoQ10 的血液水平，因此建议癌症患者使用 CoQ10 补充剂进行治疗。CoQ10 补充剂的抗癌作用已在多种癌症中得到报道，包括结肠癌和乳腺癌。CoQ10 可以清除自由基，减轻氧化应激，最大限度地减少组织损伤。CoQ10 通过减少炎症细胞因子和其他炎症因子的产生，来减轻化疗药物对身体的损害。最近的研究表明，CoQ10 可能是肝细胞癌药物治疗的一种补充。本文探讨了 CoQ10 在肝细胞癌中的作用。
