Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia - LAPEMI, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
Laboratório de Bioinorgânica e Materiais Porfirínicos (LBMP), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
Photodiagnosis Photodyn Ther. 2021 Dec;36:102550. doi: 10.1016/j.pdpdt.2021.102550. Epub 2021 Sep 25.
This manuscript reports enhanced antimicrobial photoinactivation using tetra-cationic porphyrins with peripheral platinum(II) and palladium(II) complexes against fungal dermatophyte strains. Six different positively charged porphyrins were used and applied in antimicrobial photodynamic therapy experiments (aPDT) against dermatophyte fungi colonies. The microbiological tests were conducted with an adequate concentration of photosensitizer (PS) under white-light irradiation for 120 min and the most effective PS meta isomer 3PtP significantly reduced the concentration of viable fungal colony. In this way, tetra-cationic porphyrins containing platinum(II)-bipyridyl complexes may be promising fungicidal aPDT agents with potential applications in future clinical cases.
这篇手稿报告了使用带有外围铂(II)和钯(II)配合物的四阳离子卟啉来增强抗微生物光动力杀菌作用，以对抗真菌性皮肤癣菌菌株。使用了六种不同的正电荷卟啉，并将其应用于抗真菌性皮肤癣菌真菌菌落的抗菌光动力疗法实验(aPDT)中。微生物学测试是在适当浓度的光敏剂(PS)下进行的，在白光照射下照射 120 分钟，最有效的 PS 顺式异构体 3PtP 显著降低了真菌菌落的存活浓度。通过这种方式，含有铂(II)-联吡啶配合物的四阳离子卟啉可能是有前途的杀真菌 aPDT 剂，具有在未来临床病例中的潜在应用。
