Department of Molecular Cell Biology, School of Medicine, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 1JQ, UK.
Cells. 2021 Aug 26;10(9):2199. doi: 10.3390/cells10092199.
Cellular therapy is a promising tool of human medicine to successfully treat complex and challenging pathologies such as cardiovascular diseases or chronic inflammatory conditions. Bone marrow-derived mesenchymal stromal cells (BMSCs) are in the limelight of these efforts, initially, trying to exploit their natural properties by direct transplantation. Extensive research on the therapeutic use of BMSCs shed light on a number of key aspects of BMSC physiology including the importance of oxygen in the control of BMSC phenotype. These efforts also led to a growing number of evidence indicating that the beneficial therapeutic effects of BMSCs can be mediated by BMSC-secreted agents. Further investigations revealed that BMSC-excreted extracellular vesicles could mediate the potentially therapeutic effects of BMSCs. Here, we review our current understanding of the relationship between low oxygen conditions and the effects of BMSC-secreted extracellular vesicles focusing on the possible medical relevance of this interplay.
细胞疗法是人类医学中一种有前途的工具，可成功治疗心血管疾病或慢性炎症等复杂和具有挑战性的疾病。骨髓间充质基质细胞（BMSCs）是这些努力的焦点，最初试图通过直接移植利用其天然特性。对 BMSCs 治疗用途的广泛研究揭示了 BMSC 生理学的许多关键方面，包括氧气在控制 BMSC 表型中的重要性。这些努力还导致越来越多的证据表明，BMSCs 的有益治疗效果可以通过 BMSC 分泌的因子来介导。进一步的研究表明，BMSC 分泌的细胞外囊泡可以介导 BMSCs 的潜在治疗效果。在这里，我们回顾了我们目前对低氧条件与 BMSC 分泌的细胞外囊泡作用之间关系的理解，重点关注这种相互作用的可能医学相关性。
