Prognostic Roles of , , , and Mutations in Mucosal Melanomas.

BACKGROUND

The prognostic value of commonly recurrent mutations remains unclear in mucosal melanomas.

METHODS

Clinicopathologic parameters of 214 cases of mucosal melanomas diagnosed in 1989-2020 in several clinical institutions were analyzed. , , , and mutational analyses by Sanger sequencing and next generation sequencing-based assay were performed in a subset of cases.

RESULTS

Of the triple (, , )-negative cases, , and are detected mainly in sinonasal, vulvovaginal and anorectal melanomas, respectively. , , , and mutations are detected in 19% (37/198), 22% (44/197), 12% (25/201), 16% (22/138) and 15% (20/133) of cases, respectively. In univariate analyses, advanced stage ( = 0.016), 65 years or older ( = 0.048) and presence of ulceration ( = 0.027) are significantly correlated with worse overall survival (OS), respectively. mutation significantly correlates with worse OS ( = 0.028) and worse melanoma-specific survival (MSS) ( = 0.03) for all cases of mucosal melanomas. In multivariate analyses, mutation remains as an independent predictor of worse OS ( = 0.036) and worse MSS ( = 0.024).

CONCLUSION

mutation is a predictor of worse survival, independent of stage in mucosal melanomas. The significance of frequently mutated in mucosal melanomas remains unclear.