Choo Stephanie, Nuelle Julia A V
Department of Orthopaedic Surgery, Missouri Orthopaedic Institute, University of Missouri, Columbia, MO 65212, USA.
Children (Basel). 2021 Sep 18;8(9):821. doi: 10.3390/children8090821.
This systematic review evaluates and synthesizes the available peer-reviewed evidence regarding the impact of non-steroidal anti-inflammatory drugs (NSAIDs) on fracture healing in skeletally immature patients. Evidence supports the use of NSAIDs in this patient population for adequate pain control without increasing the risk of nonunion, particularly in long bone fractures and pseudoarthrosis after spine fusion. However, further clinical studies are needed to fill remaining gaps in knowledge, specifically with respect to the spectrum of available NSAIDs, dosage, and duration of use, in order to make broad evidence-based recommendations regarding the optimal use of NSAIDs during bone healing in skeletally immature patients.
本系统评价评估并综合了现有同行评审证据，以探讨非甾体抗炎药（NSAIDs）对骨骼未成熟患者骨折愈合的影响。有证据支持在该患者群体中使用NSAIDs以充分控制疼痛，且不增加骨不连风险，尤其是在长骨骨折和脊柱融合术后假关节形成的情况下。然而，仍需进一步的临床研究来填补知识空白，特别是关于可用NSAIDs的种类、剂量和使用持续时间，以便就骨骼未成熟患者骨愈合期间NSAIDs的最佳使用提出广泛的循证建议。
