Ludmir J, Main D M, Landon M B, Gabbe S G
Obstet Gynecol. 1986 May;67(5):750-1. doi: 10.1097/00006250-198605000-00028.
Acetaminophen is a common drug used in pregnancy. A 32-year-old woman ingested 64 g of acetaminophen at 15 weeks of gestation. Treatment with N-acetylcysteine was given within 24 hours. The patient nonetheless developed severe hepatic necrosis and her hospital course was complicated by adult respiratory distress syndrome. With aggressive supportive treatment, the mother survived and delivered a viable infant at 32 weeks' gestation. The possible mechanisms of acetaminophen toxicity in the mother and the fetus are discussed.
对乙酰氨基酚是孕期常用药物。一名32岁女性在妊娠15周时摄入了64克对乙酰氨基酚。在24小时内给予了N - 乙酰半胱氨酸治疗。尽管如此，患者仍发生了严重的肝坏死，其住院过程因成人呼吸窘迫综合征而复杂化。经过积极的支持治疗，母亲存活下来，并在妊娠32周时产下一名存活婴儿。文中讨论了对乙酰氨基酚对母亲和胎儿产生毒性的可能机制。
