Bruno Barbara, Troìa Roberta, Dondi Francesco, Maurella Cristiana, Gianella Paola, Lippi Ilaria, Tarducci Alberto, Borrelli Antonio
Department of Veterinary Science, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, Torino, Italy.
Department of Veterinary Medical Science, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell'Emilia, Bologna, Italy.
Animals (Basel). 2021 Aug 31;11(9):2555. doi: 10.3390/ani11092555.
In veterinary medicine, investigations relating the effects of hydroxyethyl starch (HES) on renal function report contrasting results. This study aimed to assess the changes in the selected biomarkers of kidney injury in dogs after the administration of HES 130/0.4 as a constant rate infusion (CRI) for 24 h. Ten adult client-owned dogs with hypoalbuminemia (albumin < 2 g/dL) and ongoing fluid losses were included. Enrolled dogs received intravenous fluid therapy with crystalloids and a CRI of HES 130/0.4 at a dose of 2 mL/kg/h for 24 h. Serum creatinine (sCr), fractional excretion (FE) of electrolytes, urinary protein to creatinine ratio (UPC), urinary albumin to creatinine ratio (UAC), SDS-page, and urinary neutrophil gelatinase-associated lipocalin (uNGAL) were measured at the baseline before HES infusion, and after 24 h (T24) and 48 h (T48) from the baseline. No statistically significant difference was found between the baseline value vs. T24 and the baseline vs. T48 for sCr, UAC, UPC, FE of sodium, chloride and calcium, and uNGAL. A significant increase in FEK ( = 0.04) was noticed between the baseline and T48. In this study sample of hypoalbuminemic dogs, HES 130/0.4 at the dose and rate of infusion applied did not cause any significant changes in the investigated biomarkers of kidney injury.
在兽医学中，关于羟乙基淀粉（HES）对肾功能影响的研究报告了相互矛盾的结果。本研究旨在评估以24小时持续输注（CRI）方式给予130/0.4的HES后，犬肾损伤选定生物标志物的变化。纳入了10只患有低白蛋白血症（白蛋白<2 g/dL）且持续有液体丢失的成年客户拥有的犬。入选的犬接受晶体液静脉输液治疗，并以2 mL/kg/h的剂量接受130/0.4的HES持续输注24小时。在输注HES前的基线、基线后24小时（T24）和基线后48小时（T48）测量血清肌酐（sCr）、电解质的分数排泄（FE）、尿蛋白与肌酐比值（UPC）、尿白蛋白与肌酐比值（UAC）、SDS-聚丙烯酰胺凝胶电泳以及尿中性粒细胞明胶酶相关脂质运载蛋白（uNGAL）。对于sCr、UAC、UPC、钠、氯和钙的FE以及uNGAL，在基线值与T24之间以及基线与T48之间未发现统计学上的显著差异。在基线和T48之间观察到FEK有显著增加（P = 0.04）。在本低白蛋白血症犬的研究样本中，以所应用的剂量和输注速率使用130/0.4的HES并未导致所研究的肾损伤生物标志物出现任何显著变化。
