Garrido-Castro Juan L, Aranda-Valera I Concepción, Peña-Amaro José, Martínez-Galisteo Alfonso, González-Navas Cristina, Rodrigues-de-Souza Daiana P, Alcaraz-Clariana Sandra, García-Luque Lourdes, Sánchez Iago R Martínez, López-Medina Clementina, Collantes-Estévez Eduardo, Alburquerque-Sendín Francisco
Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain.
Department of Rheumatology, University Hospital Reina Sofía, 14004 Cordoba, Spain.
Diagnostics (Basel). 2021 Sep 10;11(9):1662. doi: 10.3390/diagnostics11091662.
Axial spondyloarthritis (axSpA) affects spinal muscles, due to inflammation and structural damage. The mechanical properties of the muscles, such as tone or stiffness, could be altered in axSpA. The aim of this work is to analyze the mechanical properties of cervical and lumbar spine muscles in axSpA patients and their relationship with metrology measures, function, disease activity, structural damage and quality of life.
axSpA patients and age/gender/BMI matched healthy controls were recruited. The muscle mechanical properties (MMPs), such as tone or frequency, stiffness, decrement (linear elastic properties), relaxation and creep (viscoelastic properties), of cervical (semispinalis capitis) and lumbar (erector spinae) muscles were bilaterally measured at rest using myotonometry. Additionally, conventional metrology, BASMI (metrology index), BASDAI (disease activity index), mSASSS (radiological structural damage index) and SF-12 (health-related quality of life questionnaire) were used in the axSpA group. Between-groups comparison, intra-group correlations and multivariable regression analyses were performed to achieve the study aims.
Thirty-four axSpA patients (mean age: 46.21 ± 8.53 y) and 34 healthy volunteers (mean age: 43.97 ± 8.49 y) were recruited. Both in cervical and lumbar spine, linear elastic parameters were significantly higher in axSpA patients in comparison with controls, while viscoelastic parameters were significantly lower. Lumbar muscle frequency, stiffness, relaxation, creep and cervical muscle elasticity were fair to strongly correlated (|0.346| < r < |0.774|) with age, functional status, activity of disease, structural damage and quality of life in axSpA patients. Furthermore, moderate to good fitted multivariate models (0.328 < R < 0.697) were obtained combining age, conventional metrology, activity of the disease and function for the estimation of cervical and lumbar MMPs.
Mechanical properties of spinal muscles of axSpA patients differ from controls. Lumbar and cervical muscles exhibit greater linear elastic properties and lower viscoelastic properties, which are related with age, clinical and psychophysiological features of axSpA.
轴性脊柱关节炎（axSpA）会因炎症和结构损伤影响脊柱肌肉。axSpA患者肌肉的力学特性，如张力或僵硬度，可能会发生改变。本研究旨在分析axSpA患者颈椎和腰椎肌肉的力学特性及其与计量学指标、功能、疾病活动度、结构损伤和生活质量的关系。
招募axSpA患者以及年龄、性别、体重指数相匹配的健康对照者。使用肌动测量法在静息状态下双侧测量颈椎（头半棘肌）和腰椎（竖脊肌）肌肉的力学特性（MMPs），如张力或频率、僵硬度、衰减（线性弹性特性）、松弛和蠕变（粘弹性特性）。此外，在axSpA组中使用了传统计量学、BASMI（计量学指数）、BASDAI（疾病活动指数）、mSASSS（放射学结构损伤指数）和SF - 12（健康相关生活质量问卷）。进行组间比较、组内相关性分析和多变量回归分析以实现研究目的。
招募了34例axSpA患者（平均年龄：46.21±8.53岁）和34名健康志愿者（平均年龄：43.97±8.49岁）。与对照组相比，axSpA患者颈椎和腰椎的线性弹性参数均显著更高，而粘弹性参数显著更低。axSpA患者腰椎肌肉的频率、僵硬度、松弛、蠕变以及颈椎肌肉的弹性与年龄、功能状态、疾病活动度、结构损伤和生活质量呈中等至强相关性（|0.346| < r < |0.774|）。此外，结合年龄、传统计量学、疾病活动度和功能，获得了拟合度中等至良好的多变量模型（0.328 < R < 0.697）用于估计颈椎和腰椎的MMPs。
axSpA患者脊柱肌肉的力学特性与对照组不同。腰椎和颈椎肌肉表现出更大的线性弹性特性和更低的粘弹性特性，这与axSpA的年龄、临床和心理生理特征相关。
