Kim Dong Hwan, Choi Sang Hyun, Shim Ju Hyun, Kim So Yeon, Lee Seung Soo, Byun Jae Ho, Kim Kyung Won, Choi Joon-Il
Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Diagnostics (Basel). 2021 Sep 12;11(9):1665. doi: 10.3390/diagnostics11091665.
Our meta-analysis aimed to evaluate the diagnostic performance of surveillance magnetic resonance imaging (sMRI) for detecting hepatocellular carcinoma (HCC), and to compare the diagnostic performance of sMRI between different protocols. Original articles about the diagnostic accuracy of sMRI for detecting HCC were found in major databases. The meta-analytic pooled sensitivity and specificity of sMRI for detecting HCC were determined using a bivariate random effects model. The pooled sensitivity and specificity of full MRI and abbreviated MRI protocols were compared using bivariate meta-regression. In the total seven included studies (1830 patients), the pooled sensitivity of sMRI for any-stage HCC and very early-stage HCC were 85% (95% confidence interval, 79-90%; = 0%) and 77% (66-85%; = 32%), respectively. The pooled specificity for any-stage HCC and very early-stage HCC were 94% (90-97%; = 94%) and 94% (88-97%; = 96%), respectively. The pooled sensitivity and specificity of abbreviated MRI protocols were 87% (80-94%) and 94% (90-98%), values that were comparable with those of full MRI protocols (84% [76-91%] and 94% [89-99%]; = 0.83). In conclusion, sMRI had good sensitivity for detecting HCC, particularly very early-stage HCC. Abbreviated MRI protocols for HCC surveillance had comparable diagnostic performance to full MRI protocols.
我们的荟萃分析旨在评估监测磁共振成像（sMRI）检测肝细胞癌（HCC）的诊断性能，并比较不同方案之间sMRI的诊断性能。在主要数据库中查找了关于sMRI检测HCC诊断准确性的原始文章。使用双变量随机效应模型确定sMRI检测HCC的荟萃分析合并敏感性和特异性。使用双变量元回归比较了全MRI和简化MRI方案的合并敏感性和特异性。在总共纳入的7项研究（1830例患者）中，sMRI对任何阶段HCC和极早期HCC的合并敏感性分别为85%（95%置信区间，79-90%；I² = 0%）和77%（66-85%；I² = 32%）。对任何阶段HCC和极早期HCC的合并特异性分别为94%（90-97%；I² = 94%）和94%（88-97%；I² = 96%）。简化MRI方案的合并敏感性和特异性分别为87%（80-94%）和94%（90-98%），这些值与全MRI方案的合并敏感性和特异性（84% [76-91%]和94% [89-99%]；P = 0.83）相当。总之，sMRI检测HCC具有良好的敏感性，尤其是极早期HCC。用于HCC监测的简化MRI方案与全MRI方案具有相当的诊断性能。
