Santana-Garrido Álvaro, Reyes-Goya Claudia, Milla-Navarro Santiago, de la Villa Pedro, André Helder, Vázquez Carmen M, Mate Alfonso
Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain.
Epidemiología Clínica y Riesgo Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Sevilla, Spain.
Foods. 2021 Aug 25;10(9):1993. doi: 10.3390/foods10091993.
Inflammation plays a crucial role in the course of eye diseases, including many vascular retinopathies. Although olive oil is known to have beneficial effects against inflammatory processes, there is no information available on the anti-inflammatory potential of the wild olive tree (namely, acebuche (ACE) for the primitive Spanish lineages). Here we investigate the anti-inflammatory effects of ACE oil in the retina of a mouse model of arterial hypertension, which was experimentally induced by administration of L-NAME (NG-nitro-L-arginine-methyl-ester). The animals were fed supplements of ACE oil or extra virgin olive oil (EVOO, for comparative purposes). Retinal function was assessed by electroretinography (ERG), and different inflammation-related parameters were measured in the retina and choroid. Besides significant prevention of retinal dysfunction shown in ERG recordings, ACE oil-enriched diet upregulated the expression of the anti-inflammatory markers PPARγ, PPARα and IL-10, while reducing that of major proinflammatory biomarkers, IL-1β, IL-6, TNF-α and COX-2. This is the first report to highlight the anti-inflammatory properties of an ACE oil-enriched diet against hypertension-related retinal damage. Noteworthy, dietary supplementation with ACE oil yielded better results compared to a reference EVOO.
炎症在眼部疾病进程中起着关键作用，包括许多视网膜血管病变。尽管已知橄榄油对炎症过程具有有益作用，但关于野生油橄榄树（即原始西班牙谱系中的阿塞布切（ACE））的抗炎潜力尚无相关信息。在此，我们研究了ACE油对动脉高血压小鼠模型视网膜的抗炎作用，该模型是通过给予L-NAME（NG-硝基-L-精氨酸甲酯）实验诱导产生的。给动物喂食ACE油补充剂或特级初榨橄榄油（EVOO，用于比较）。通过视网膜电图（ERG）评估视网膜功能，并在视网膜和脉络膜中测量不同的炎症相关参数。除了ERG记录显示出对视网膜功能障碍的显著预防作用外，富含ACE油的饮食上调了抗炎标志物PPARγ、PPARα和IL-10的表达，同时降低了主要促炎生物标志物IL-1β、IL-6、TNF-α和COX-2的表达。这是第一份强调富含ACE油的饮食对高血压相关视网膜损伤具有抗炎特性的报告。值得注意的是，与参考EVOO相比，用ACE油进行饮食补充产生了更好的效果。
