Research Centre for Applied Sport, Physical Activity and Performance, School of Sport & Health Sciences, Faculty of Allied Health and Wellbeing, University of Central Lancashire, Preston PR1 2HE, UK.
Centre for Research in Psychology and Sport Sciences, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
Int J Environ Res Public Health. 2021 Sep 16;18(18):9759. doi: 10.3390/ijerph18189759.
Cardiometabolic disease is recognized as the predominant cause of global mortality and healthcare expenditure. Whilst pharmaceutical interventions are effective in the short term, their long-term efficacy remain equivocal and their associated side-effects are concerning. Owing to their high levels of anthocyanins, Montmorency tart cherries and blueberries have been cited as potentially important natural treatment/preventative modalities for cardiometabolic disease. This study proposed a randomized controlled trial, aims to test the effects of consumption of Montmorency tart cherry and blueberry juice on cardiometabolic outcomes compared to placebo. This 20-day, parallel, single-blind, randomized, placebo-controlled trial will recruit 45 individuals, who will be assigned to receive 60 mL per day of either Montmorency tart cherry juice, blueberry juice or a cherry/blueberry flavoured placebo. The primary study outcome is the between-group difference in systolic blood pressure from baseline to post-intervention. Secondary outcome measures will be between-group differences in anthropometric, energy expenditure and substrate oxidation (during rest and physical activity), haematological, blood pressure/resting heart rate, psychological wellbeing and sleep efficacy indices. Statistical analysis will be conducted on an intention-to-treat basis. This study has been granted ethical approval by the University of Central Lancashire, Health Research Ethics Committee (ref: HEALTH 0016) and formally registered as a trial. Dissemination of the study findings from this investigation will be through publication in a leading peer-reviewed journal.
心血管代谢疾病被认为是全球死亡率和医疗保健支出的主要原因。虽然药物干预在短期内有效，但它们的长期疗效仍存在争议，其相关副作用令人担忧。由于 Montmorency 酸樱桃和蓝莓含有高水平的花青素，因此被认为是心血管代谢疾病潜在的重要天然治疗/预防方法。本研究提出了一项随机对照试验，旨在测试与安慰剂相比，食用 Montmorency 酸樱桃和蓝莓汁对心血管代谢结果的影响。这项为期 20 天、平行、单盲、随机、安慰剂对照试验将招募 45 名参与者，他们将被分配每天饮用 60 毫升的 Montmorency 酸樱桃汁、蓝莓汁或樱桃/蓝莓风味的安慰剂。主要研究结果是干预后与基线相比，收缩压的组间差异。次要结果测量将包括人体测量学、能量消耗和底物氧化（在休息和体力活动期间）、血液学、血压/静息心率、心理幸福感和睡眠效果指数的组间差异。将根据意向治疗原则进行统计分析。该研究已获得中央兰开夏大学健康研究伦理委员会（编号：HEALTH 0016）的伦理批准，并正式注册为试验。本研究的研究结果将通过在领先的同行评议期刊上发表来传播。
