Seitz Christian, Eisenreich Wolfgang, Huber Claudia
Bayerisches NMR Zentrum, Strukturelle Membranbiochemie, Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85748 Garching, Germany.
Life (Basel). 2021 Sep 17;11(9):980. doi: 10.3390/life11090980.
Porphyrins, corrins, and tetrapyrroles constitute macrocycles in essential biomolecules such as heme, chlorophyll, cobalamin, and cofactor F430. The chemical synthesis as well as the enzymatic synthesis of these macrocycles starts from pyrrole derivatives. We here show that pyrrole and dimethyl pyrrole can be formed under the simulated volcanic, hydrothermal conditions of Early Earth, starting from acetylene, propyne, and ammonium salts in the presence of NiS or CoS as catalysts.
卟啉、咕啉和四吡咯构成了血红素、叶绿素、钴胺素和辅因子F430等重要生物分子中的大环结构。这些大环结构的化学合成以及酶促合成均起始于吡咯衍生物。我们在此表明，在早期地球模拟火山热液条件下，以乙炔、丙炔和铵盐为原料，在硫化镍或硫化钴作为催化剂存在的情况下，可以形成吡咯和二甲基吡咯。
