Muñoz-Hernández Patricia, Valdivia-Mazeyra Mariel, Ancochea Julio, Alonso Pérez Tamara, Rajas Olga, Valenzuela Claudia, Hernández-Muñiz Susana, Esteban-Peris Amparo, Jiménez-Heffernan José A
Department of Pathology, University Hospital La Princesa, Diego de León, 62, 28006 Madrid, Spain.
Department of Pneumology, University Hospital La Princesa, Diego de León, 62, 28006 Madrid, Spain.
J Clin Med. 2021 Sep 15;10(18):4151. doi: 10.3390/jcm10184151.
There is a relationship between systemic sarcoidosis (SS) and malignancy. Sarcoidosis results from an exaggerated immune response in genetically susceptible individuals. In oncologic patients with sarcoidosis, tumoral antigens and antineoplastic treatment are considered potential triggering factors. The observation of a patient with granulomas in a parotid carcinoma who later developed SS led us to review the previous tumors of patients with SS. The aim of the study is to see whether granulomas were already present in the tumors that preceded sarcoidosis. We identified 196 sarcoidosis patients, 47 of whom had previously had a tumor. We were able to review 29 cases, 12 of which showed tumor-associated granulomas (TAGs) (41.4%). This ratio is much higher than that of the normal population (4.4-13.8). We analyzed five control patients without sarcoidosis for each tumor. In conclusion, we observed an increased number of TAGs in patients who later developed SS. This finding reinforces a pathogenic relationship between SS and neoplasia. The histology of tumors in patients with SS should be reviewed in an attempt to identify granulomas.
系统性结节病（SS）与恶性肿瘤之间存在关联。结节病是由遗传易感性个体的过度免疫反应引起的。在患有结节病的肿瘤患者中，肿瘤抗原和抗肿瘤治疗被认为是潜在的触发因素。一名腮腺癌患者出现肉芽肿后发展为SS，这一观察促使我们回顾SS患者先前的肿瘤情况。本研究的目的是查看在结节病之前的肿瘤中是否已经存在肉芽肿。我们确定了196例结节病患者，其中47例曾患过肿瘤。我们能够回顾29例病例，其中12例显示有肿瘤相关肉芽肿（TAGs）（41.4%）。这个比例远高于正常人群（4.4 - 13.8）。我们为每个肿瘤分析了5例无结节病的对照患者。总之，我们观察到后来发展为SS的患者中TAGs数量增加。这一发现强化了SS与肿瘤形成之间的致病关系。应对SS患者的肿瘤组织学进行检查，以试图识别肉芽肿。
