Rahman Naureen, Scott Faith Hannah, Lvov Yuri, Stavitskaya Anna, Akhatova Farida, Konnova Svetlana, Fakhrullina Gӧlnur, Fakhrullin Rawil
Institute for Micromanufacturing and Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USA.
Department of Physical and Colloid Chemistry, Gubkin University, Leninsky Pr. 65, 119991 Moscow, Russia.
Pharmaceutics. 2021 Sep 15;13(9):1477. doi: 10.3390/pharmaceutics13091477.
Topical administration of drugs is required for the treatment of parasitic diseases and insect infestations; therefore, fabrication of nanoscale drug carriers for effective insecticide topical delivery is needed. Here we report the enhanced immobilization of halloysite tubule nanoclay onto semiaquatic capybaras which have hydrophobic hair surfaces as compared to their close relatives, land-dwelling guinea pigs, and other agricultural livestock. The hair surface of mammals varies in hydrophobicity having a cortex surrounded by cuticles. Spontaneous 1-2 µm thick halloysite hair coverages on the semi-aquatic rodent capybara, non-aquatic rodent guinea pig, and farm goats were compared. The best coating was found for capybara due to the elevated 5 wt% wax content. As a result, we suggest hair pretreatment with diluted wax for enhanced nanoclay adsorption. The formation of a stable goat hair coverage with a 2-3 µm halloysite layer loaded with permethrin insecticide allowed for long-lasting anti-parasitic protection, enduring multiple rain wettings and washings. We expect that our technology will find applications in animal parasitosis protection and may be extended to prolonged human anti-lice treatment.
治疗寄生虫病和昆虫侵扰需要进行药物的局部给药；因此，需要制备用于有效局部递送杀虫剂的纳米级药物载体。在此，我们报告了在半水生水豚上增强埃洛石纳米管粘土的固定化，与它们的近亲陆生豚鼠和其他家畜相比，水豚具有疏水性毛发表面。哺乳动物的毛发表面疏水性各不相同，其皮质被角质层包围。比较了半水生啮齿动物水豚、非水生啮齿动物豚鼠和农场山羊上自发形成的1-2微米厚的埃洛石毛发覆盖情况。由于蜡含量提高到5重量%，发现水豚的涂层效果最佳。因此，我们建议用稀释蜡对毛发进行预处理以增强纳米粘土的吸附。用负载有氯菊酯杀虫剂的2-3微米埃洛石层形成稳定的山羊毛发覆盖层，可实现持久的抗寄生虫保护，经受多次雨水浸湿和洗涤。我们期望我们的技术将在动物寄生虫病防护中得到应用，并可能扩展到延长人类抗虱治疗。
