Cheknev S B, Saidov M Z, Koval'chuk L V, Pavliuk A S, Arion V Ia
Biull Eksp Biol Med. 1986 Apr;101(4):455-7.
The activity of natural killers (NK) from human peripheral blood was determined by 3H-uridine test using target cells K-562. T-activin effect on the activity of human NK in vitro depended on two parameters: the preparation dose and effector/target cells ratio. The inhibitory effect of T-activin was observed with high doses and increased E/T ratio, while the activating effect was noted with low doses and reduced E/T ratio. This can be attributed to the heterogeneity of NK population, different functional role of high and low doses of thymic factors and the development of NK as T-cell precursors.
采用靶细胞K-562，通过³H-尿苷试验测定人外周血自然杀伤细胞（NK）的活性。T-激活素对人NK体外活性的影响取决于两个参数：制剂剂量和效应细胞/靶细胞比例。高剂量和增加的E/T比例时观察到T-激活素的抑制作用，而低剂量和降低的E/T比例时则有激活作用。这可归因于NK群体的异质性、高剂量和低剂量胸腺因子的不同功能作用以及NK作为T细胞前体的发育。
