Cheknev S B, Latysheva O L, Denisov L A, Ershov F I
Biull Eksp Biol Med. 1992 Feb;113(2):179-82.
The cytotoxic activity of natural killer (NK) cells isolated from peripheral blood of 20 healthy donors and 34 patients with multiple sclerosis (MS) against labelled with H3-uridine target cells K-562 before and after their 1 hr treatment with reaferon (RF), T-activin (TA), myelopid (MP), opioid preparation dalargin (DL) as well as with combinations of TA, MP and DL with RF was studied in 14 hrs cytotoxic test. It has been shown that combination of RF with TA, MP and DL changed the regulatory action of these peptides on NK cell activity in healthy donors in vitro. The same combination of the preparations in patients with MS caused another changes in regulation of NK activity by them because NK cells in MS patients had had initially changed sensitivity to action of these regulatory polypeptides.
在14小时的细胞毒性试验中，研究了从20名健康供体和34名多发性硬化症（MS）患者外周血中分离出的自然杀伤（NK）细胞在接受瑞法干扰素（RF）、T-激活素（TA）、髓磷脂（MP）、阿片制剂达拉根（DL）以及TA、MP和DL与RF的组合处理1小时前后，对用H3-尿苷标记的靶细胞K-562的细胞毒性活性。结果表明，RF与TA、MP和DL的组合改变了这些肽在体外对健康供体NK细胞活性的调节作用。MS患者中相同制剂的组合导致它们对NK活性调节的另一种变化，因为MS患者的NK细胞最初对这些调节性多肽的作用敏感性已发生改变。
