硝基亚烷基在[1,2,4]三唑并[4,3-a]喹啉和 1,3,4-恶二唑环双环化反应中的亲电活化作用。
Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-]quinolines and 1,3,4-Oxadiazole Rings.
机构信息
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
Organic Chemistry Department, Peoples' Friendship, University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia.
出版信息
Molecules. 2021 Sep 20;26(18):5692. doi: 10.3390/molecules26185692.
Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-]quinolines with 1,3,4-oxadiazole substituents.
用多聚磷酸活化的硝烷可以作为与胺和肼反应的有效亲电试剂，实现各种杂环体系的级联转化。该策略用于开发一种创新的合成方案，采用同时或顺序环合两个不同杂核的方法，得到具有 1,3,4-噁二唑取代基的[1,2,4]三唑并[4,3-a]喹啉。
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