亲电活化的硝基烷烃在 3,4-二氢喹唑啉合成中的应用。
Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines.
机构信息
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USA.
出版信息
Molecules. 2021 Jul 14;26(14):4274. doi: 10.3390/molecules26144274.
Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.
用多聚磷酸活化的硝烷作为高效的亲电试剂，与各种亲核胺反应。通过策略性地引入第二个官能团，可以设计成环反应，从而制备各种杂环。这种策略被用于开发一种从易得的 2-（氨甲基）苯胺制备 3,4-二氢喹唑啉的创新合成方法。
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