通过2-(氨基甲基)吡啶与亲电活化的硝基烷烃的环缩合反应合成咪唑并[1,5 -]吡啶。
Synthesis of imidazo[1,5-]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes.
作者信息
Aksenov Dmitrii A, Arutiunov Nikolai A, Maliuga Vladimir V, Aksenov Alexander V, Rubin Michael
机构信息
Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian Federation.
Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USA.
出版信息
Beilstein J Org Chem. 2020 Nov 26;16:2903-2910. doi: 10.3762/bjoc.16.239. eCollection 2020.
Abstract
Imidazo[1,5-]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium.
摘要
咪唑并[1,5 -]吡啶可通过在多磷酸（PPA）介质中，在亚磷酸存在下，使2 - 吡啶甲胺与经亲电活化的硝基烷烃进行环化反应高效制备。
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