Yan Qinying, Weng Jiaqi, Shen Shulin, Wang Yan, Fang Min, Zheng Gensuo, Yang Qingliang, Yang Gensheng
College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310032, China.
Polymers (Basel). 2021 Sep 9;13(18):3043. doi: 10.3390/polym13183043.
In this study, a micro-molding technology was used to prepare the microneedles (MNs), while a texture analyzer was used to measure its Young's modulus, Poisson's ratio and compression breaking force, to evaluate whether the MNs can penetrate the skin. The effects of different materials were characterized by their ability to withstand stresses using the Structural Mechanics Module of COMSOL Multiphysics. Carboxymethylcellulose (CMC) was chosen as the needle formulation material with varying quantities of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and hyaluronic acid (HA) to adjust the viscosity, brittleness, hardness and solubility of the material. The results of both the experimental tests and the predictions indicated that the hardest tip material had a solids content of 15% (w/w ) with a 1:2 (w/w) CMC: HA ratio. Furthermore, it was shown that a solid content of 10% (w/w) with a 1:5 (w/w) CMC: PVA ratio is suitable for making patches. The correlation between the mechanical properties and the different materials was found using the simulation analysis as well as the force required for different dissolving microneedles (DMNs) to penetrate the skin, which significantly promoted the research progress of microneedle transdermal drug delivery.
在本研究中，采用微成型技术制备微针（MNs），同时使用纹理分析仪测量其杨氏模量、泊松比和压缩断裂力，以评估微针是否能够穿透皮肤。利用COMSOL Multiphysics的结构力学模块，通过不同材料承受应力的能力来表征其效果。选择羧甲基纤维素（CMC）作为针剂配方材料，并加入不同量的聚乙烯吡咯烷酮（PVP）、聚乙烯醇（PVA）和透明质酸（HA）来调节材料的粘度、脆性、硬度和溶解性。实验测试和预测结果均表明，最硬的尖端材料的固含量为15%（w/w），CMC与HA的比例为1:2（w/w）。此外，结果表明，固含量为10%（w/w），CMC与PVA的比例为1:5（w/w）适合制作贴片。通过模拟分析以及不同溶解微针（DMNs）穿透皮肤所需的力，发现了力学性能与不同材料之间的相关性，这显著推动了微针透皮给药的研究进展。
