Demina Tatiana S, Kilyashova Liubov A, Popyrina Tatiana N, Svidchenko Eugenia A, Bhuniya Sankarprasad, Akopova Tatiana A, Grandfils Christian
Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsouznaya Str., 117393 Moscow, Russia.
Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya Str., 119991 Moscow, Russia.
Polymers (Basel). 2021 Sep 9;13(18):3045. doi: 10.3390/polym13183045.
Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evaluate the effectiveness of various polysaccharides, such as chitosan, hyaluronic acid, cellulose, arabinogalactan, guar and their derivatives, as an alternative to synthetic surfactants for polylactide microparticle stabilization during their fabrication. Targeted modification of the biopolymer's chemical structure was also tested as a tool to enhance polysaccharides' emulsifying ability. The transformation of biomacromolecules into a form of nanoparticle via bottom-up or top-down methods and their subsequent application for microparticle fabrication via the Pickering emulsion solvent evaporation technique was useful as a one-step approach towards the preparation of core/shell microparticles. The effect of polysaccharides' chemical structure and the form of their application on the polylactide microparticles' total yield, size distribution and morphology was evaluated. The application of polysaccharides has great potential in terms of the development of green chemistry and the biocompatibility of the formed microparticles, which is especially important in biomedicine application.
可生物降解的聚合物微粒广泛应用于具有缓释特性的药物递送系统和/或细胞微载体。通过油/水乳液溶剂蒸发技术制备这些微粒通常需要在水相中使用乳化剂。本研究旨在评估各种多糖，如壳聚糖、透明质酸、纤维素、阿拉伯半乳聚糖、瓜尔胶及其衍生物，作为合成表面活性剂的替代品在聚丙交酯微粒制备过程中稳定化作用的有效性。还测试了对生物聚合物化学结构进行靶向修饰作为增强多糖乳化能力的一种手段。通过自下而上或自上而下的方法将生物大分子转化为纳米颗粒形式，并随后通过皮克林乳液溶剂蒸发技术将其应用于微粒制备，这是制备核/壳微粒的一种一步法。评估了多糖的化学结构及其应用形式对聚丙交酯微粒的总产率、尺寸分布和形态的影响。多糖的应用在绿色化学发展以及所形成微粒的生物相容性方面具有巨大潜力，这在生物医学应用中尤为重要。
