Cao Yubiao, Chen Zhuowen, Sun Liangliang, Lin Yameng, Yang Ye, Cui Xiuming, Wang Chengxiao
School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming 650500, China.
Pharmaceutics. 2022 Aug 15;14(8):1703. doi: 10.3390/pharmaceutics14081703.
Herb polysaccharides (HPS) have been studied extensively for their healthcare applications. Though the toxicity was not fully clarified, HPS were widely accepted for their biodegradability and biocompatibility. In addition, as carbohydrate polymers with a unique chemical composition, molecular weight, and functional group profile, HPS can be conjugated, cross-linked, and functionally modified. Thus, they are great candidates for the fabrication of drug delivery systems (DDS). HPS-based DDS (HPS-DDS) can bypass phagocytosis by the reticuloendothelial system, prevent the degradation of biomolecules, and increase the bioavailability of small molecules, thus exerting therapeutic effects. In this review, we focus on the application of HPS as components of immunoregulatory DDS. We summarize the principles governing the fabrication of HPS-DDS, including nanoparticles, micelles, liposomes, microemulsions, hydrogels, and microneedles. In addition, we discuss the role of HPS in DDS for immunotherapy. This comprehensive review provides valuable insights that could guide the design of effective HPS-DDS.
草药多糖（HPS）因其医疗保健应用而受到广泛研究。尽管其毒性尚未完全阐明，但HPS因其生物可降解性和生物相容性而被广泛接受。此外，作为具有独特化学组成、分子量和官能团分布的碳水化合物聚合物，HPS可以进行共轭、交联和功能修饰。因此，它们是制备药物递送系统（DDS）的理想候选者。基于HPS的DDS（HPS-DDS）可以绕过网状内皮系统的吞噬作用，防止生物分子降解，并提高小分子的生物利用度，从而发挥治疗作用。在本综述中，我们重点关注HPS作为免疫调节DDS组件的应用。我们总结了制备HPS-DDS的原理，包括纳米颗粒、胶束、脂质体、微乳液、水凝胶和微针。此外，我们讨论了HPS在免疫治疗DDS中的作用。这一全面综述提供了有价值的见解，可指导有效HPS-DDS的设计。
