Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
LaMontagne Center for Infectious Disease, The University of Texas at Austin, Austin, TX 78712, USA.
Viruses. 2021 Sep 21;13(9):1881. doi: 10.3390/v13091881.
Viruses are obligate intracellular parasites that are dependent on host factors for their replication. One such host protein, p97 or the valosin-containing protein (VCP), is a highly conserved AAA ATPase that facilitates replication of diverse RNA- and DNA-containing viruses. The wide range of cellular functions attributed to this ATPase is consistent with its participation in multiple steps of the virus life cycle from entry and uncoating to viral egress. Studies of VCP/p97 interactions with viruses will provide important information about host processes and cell biology, but also viral strategies that take advantage of these host functions. The critical role of p97 in viral replication might be exploited as a target for development of pan-antiviral drugs that exceed the capability of virus-specific vaccines or therapeutics.
病毒是专性细胞内寄生虫，其复制依赖于宿主因子。宿主蛋白 p97 或包含缬氨酸的蛋白（VCP）就是这样一种蛋白，它是一种高度保守的 AAA ATP 酶，可促进多种含 RNA 和 DNA 的病毒的复制。这种 ATP 酶具有广泛的细胞功能，这与其参与病毒生命周期的多个步骤是一致的，包括进入、脱壳到病毒释放。研究 VCP/p97 与病毒的相互作用将提供有关宿主过程和细胞生物学的重要信息，以及病毒利用这些宿主功能的策略。p97 在病毒复制中的关键作用可能被用作开发泛抗病毒药物的靶点，这些药物的能力超过了病毒特异性疫苗或疗法。
