印度尼西亚冠状病毒疫苗接种后急性缺血性脑卒中的发病情况：病例系列研究。
Acute Ischaemic Stroke Incidence after Coronavirus Vaccine in Indonesia: Case Series.
机构信息
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia | Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia.
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
出版信息
Curr Neurovasc Res. 2021;18(3):360-363. doi: 10.2174/1567202618666210927095613.
Abstract
BACKGROUND
Coronavirus disease-19 (COVID-19) is an infectious disease with high morbidity and mortality rates. Indonesia had reported a 2.8% of mortality rate up to June 2021.
CASE PRESENTATION
A strategy to control the virus spreading is by vaccination. The Indonesian Food and Drug Monitoring Agency had approved the use of CoronaVac, an inactivated virus vaccine developed by Sinovac. Most Adverse Events Following Immunization (AEFI) for Corona- Vac are mild, and the most common symptoms are injection-site pain, headache, and fatigue. Neurovascular adverse events, including thrombosis or ischaemic stroke after receiving CoronaVac have not previously been reported.
CONCLUSION
Correspondingly, we reported three patients with an Acute Ischaemic Stroke (AIS) after the administration of CoronaVac in our hospital.
摘要
背景
新型冠状病毒肺炎（COVID-19）是一种具有高发病率和死亡率的传染病。截至 2021 年 6 月，印度尼西亚报告的死亡率为 2.8%。
病例介绍
控制病毒传播的策略是接种疫苗。印度尼西亚食品和药物监测局已批准使用科兴公司开发的灭活病毒疫苗 CoronaVac。CoronaVac 最常见的不良反应（AEFI）为轻度，最常见的症状是注射部位疼痛、头痛和疲劳。接种 CoronaVac 后发生的神经血管不良事件，包括血栓形成或缺血性中风，以前尚未报道过。
结论
相应地，我们报告了在我们医院中，有 3 名患者在接种 CoronaVac 后发生急性缺血性脑卒中（AIS）。
相似文献
1
Acute Ischaemic Stroke Incidence after Coronavirus Vaccine in Indonesia: Case Series.印度尼西亚冠状病毒疫苗接种后急性缺血性脑卒中的发病情况：病例系列研究。
Curr Neurovasc Res. 2021;18(3):360-363. doi: 10.2174/1567202618666210927095613.
2
COVID-19 Vaccines Programs: adverse events following immunization (AEFI) among medical Clerkship Student in Jember, Indonesia.COVID-19 疫苗计划：印度尼西亚井里汶医学实习学生中的疫苗接种后不良反应（AEFI）。
BMC Pharmacol Toxicol. 2021 Oct 12;22(1):58. doi: 10.1186/s40360-021-00528-4.
3
Stroke Among SARS-CoV-2 Vaccine Recipients in Mexico: A Nationwide Descriptive Study.墨西哥 SARS-CoV-2 疫苗接种者中的中风：一项全国描述性研究。
Neurology. 2022 May 10;98(19):e1933-e1941. doi: 10.1212/WNL.0000000000200388. Epub 2022 Mar 11.
4
Safety profile of inactivated COVID-19 in healthy adults aged ≥ 18 years: A passive surveillance in Indonesia.在≥18 岁健康成年人中使用灭活 COVID-19 疫苗的安全性概况：印度尼西亚的一项被动监测。
PLoS One. 2023 Oct 12;18(10):e0286484. doi: 10.1371/journal.pone.0286484. eCollection 2023.
5
Sex-based differences in risk of ischaemic stroke or systemic embolism after BNT162b2 or CoronaVac COVID-19 vaccination in patients with atrial fibrillation: a self-controlled case series and nested case-control study.性别对 BNT162b2 或 CoronaVac 新冠疫苗接种后房颤患者发生缺血性卒中或全身性栓塞风险的影响：一项自身对照病例系列和巢式病例对照研究。
Eur Heart J Cardiovasc Pharmacother. 2023 Jul 29;9(5):403-412. doi: 10.1093/ehjcvp/pvad015.
6
Adverse events following immunization of COVID-19 vaccine among children aged 6-11 years.6-11 岁儿童接种 COVID-19 疫苗后的不良反应。
Front Public Health. 2022 Oct 25;10:999354. doi: 10.3389/fpubh.2022.999354. eCollection 2022.
7
8
Incidence and clinical characteristics of adverse neurological events and stroke-like syndrome associated with immune stress-related response after COVID-19 vaccination in 2021 from Thailand.2021 年泰国 COVID-19 疫苗接种后免疫应激相关反应致不良神经系统事件和类似中风综合征的发生率及临床特征。
Clin Neurol Neurosurg. 2023 Aug;231:107804. doi: 10.1016/j.clineuro.2023.107804. Epub 2023 May 29.
9
A randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of SARS-CoV-2 vaccine (inactivated, Vero cell): a structured summary of a study protocol for a randomised controlled trial.一项评估 SARS-CoV-2 疫苗（灭活，Vero 细胞）有效性和安全性的随机、双盲、安慰剂对照 III 期临床试验：一项随机对照试验研究方案的结构化总结。
Trials. 2021 Apr 13;22(1):276. doi: 10.1186/s13063-021-05180-1.
10
Safety of Inactivated and mRNA COVID-19 Vaccination Among Patients Treated for Hypothyroidism: A Population-Based Cohort Study.甲状腺功能减退症患者接种灭活新冠疫苗和 mRNA 新冠疫苗的安全性：一项基于人群的队列研究。
Thyroid. 2022 May;32(5):505-514. doi: 10.1089/thy.2021.0684. Epub 2022 Apr 7.
引用本文的文献
1
COVID-19 vaccines and neurological disorders: A narrative review of immune responses and adverse reactions.新冠病毒疫苗与神经系统疾病：免疫反应和不良反应的叙述性综述
AIMS Neurosci. 2025 Jun 18;12(2):222-249. doi: 10.3934/Neuroscience.2025013. eCollection 2025.
2
Neurovascular Adverse Effects of Sars-Cov-2 Vaccination.Sars-Cov-2 疫苗接种的神经血管不良影响。
Drug Des Devel Ther. 2024 May 30;18:1891-1905. doi: 10.2147/DDDT.S464394. eCollection 2024.
3
Serious neurological adverse events following immunization against SARS-CoV-2: a narrative review of the literature.2019冠状病毒病疫苗接种后的严重神经系统不良事件：文献综述
Ther Adv Drug Saf. 2023 May 21;14:20420986231165674. doi: 10.1177/20420986231165674. eCollection 2023.
4
Progressive Central Artery Occlusion, Ophthalmic Artery Occlusion, and Hemispheric Intracranial Thrombosis after COVID-19 mRNA Vaccine Application: Case Report.新冠mRNA疫苗接种后发生的进行性视网膜中央动脉阻塞、眼动脉阻塞和半球颅内血栓形成：病例报告
Case Rep Ophthalmol. 2023 Apr 18;14(1):173-179. doi: 10.1159/000529770. eCollection 2023 Jan-Dec.
5
Sex-based differences in risk of ischaemic stroke or systemic embolism after BNT162b2 or CoronaVac COVID-19 vaccination in patients with atrial fibrillation: a self-controlled case series and nested case-control study.性别对 BNT162b2 或 CoronaVac 新冠疫苗接种后房颤患者发生缺血性卒中或全身性栓塞风险的影响：一项自身对照病例系列和巢式病例对照研究。
Eur Heart J Cardiovasc Pharmacother. 2023 Jul 29;9(5):403-412. doi: 10.1093/ehjcvp/pvad015.
6
Ocular motility disorders following coronavirus disease-19 vaccination.新冠病毒病疫苗接种后的眼球运动障碍。
Graefes Arch Clin Exp Ophthalmol. 2023 Apr;261(4):1127-1139. doi: 10.1007/s00417-022-05888-z. Epub 2022 Nov 16.
7
Menstrual abnormalities post-COVID vaccination: a cross-sectional study on adult Lebanese women.接种 COVID 疫苗后出现月经异常：一项针对黎巴嫩成年女性的横断面研究。
Ir J Med Sci. 2023 Jun;192(3):1163-1170. doi: 10.1007/s11845-022-03089-5. Epub 2022 Jul 26.
8
Safety of an inactivated, whole-virion COVID-19 vaccine (CoronaVac) in people aged 60 years or older in Hong Kong: a modified self-controlled case series.在香港，60 岁及以上人群中使用灭活全病毒 COVID-19 疫苗（科兴疫苗）的安全性：一项修改后的自身对照病例系列研究。
Lancet Healthy Longev. 2022 Jul;3(7):e491-e500. doi: 10.1016/S2666-7568(22)00125-8. Epub 2022 Jul 4.
9
Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccination; a systematic review.COVID-19 疫苗接种后急性缺血性脑卒中与疫苗诱导的免疫性血栓性血小板减少症：系统评价。
J Neurol Sci. 2022 Aug 15;439:120327. doi: 10.1016/j.jns.2022.120327. Epub 2022 Jun 20.
10
Stroke after COVID-19 vaccination.新冠病毒疫苗接种后的中风
Acta Neurol Scand. 2022 Jun;145(6):787-788. doi: 10.1111/ane.13608. Epub 2022 Mar 7.
本文引用的文献
1
Ischaemic stroke as a presenting feature of ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia.缺血性中风作为ChAdOx1 nCoV-19疫苗诱导的免疫性血栓性血小板减少症的首发症状。
J Neurol Neurosurg Psychiatry. 2021 Nov;92(11):1247-1248. doi: 10.1136/jnnp-2021-326984. Epub 2021 May 25.
2
2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association.《2021年卒中与短暂性脑缺血发作患者卒中预防指南：美国心脏协会/美国卒中协会指南》
Stroke. 2021 Jul;52(7):e364-e467. doi: 10.1161/STR.0000000000000375. Epub 2021 May 24.
3
US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021.美国 2021 年 3 月 2 日至 4 月 21 日 Ad26.COV2.S 疫苗接种后出现脑静脉窦血栓形成伴血小板减少的病例报告。
JAMA. 2021 Jun 22;325(24):2448-2456. doi: 10.1001/jama.2021.7517.
4
Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study.印度尼西亚雅加达新冠肺炎的临床特征及死亡率：一项基于医院的回顾性队列研究。
Lancet Reg Health West Pac. 2021 Apr;9:100108. doi: 10.1016/j.lanwpc.2021.100108. Epub 2021 Mar 2.
5
COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far.COVID-19：具有悠久历史、流行病学和迄今进展的全球性挑战。
Molecules. 2020 Dec 23;26(1):39. doi: 10.3390/molecules26010039.
6
COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics.COVID-19 疫情爆发：历史、机制、传播、结构研究和治疗。
Infection. 2021 Apr;49(2):199-213. doi: 10.1007/s15010-020-01516-2. Epub 2020 Sep 4.
7
Recurrent ischemic stroke: Incidence, predictors, and impact on mortality.复发性缺血性卒中：发生率、预测因素及其对死亡率的影响。
Acta Neurol Scand. 2019 Jul;140(1):3-8. doi: 10.1111/ane.13093. Epub 2019 Apr 11.
8
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.氯吡格雷联合阿司匹林治疗急性小卒中或短暂性脑缺血发作。
N Engl J Med. 2013 Jul 4;369(1):11-9. doi: 10.1056/NEJMoa1215340. Epub 2013 Jun 26.
9
White matter lesion severity in mild acute ischemic stroke patients and functional outcome after 1 year.轻度急性缺血性脑卒中患者的脑白质病变严重程度与 1 年后的功能结局。
Stroke. 2012 Nov;43(11):3046-51. doi: 10.1161/STROKEAHA.111.646554. Epub 2012 Aug 30.
10
Border zone infarcts: pathophysiologic and imaging characteristics.交界区梗死：病理生理和影像学特征。
Radiographics. 2011 Sep-Oct;31(5):1201-14. doi: 10.1148/rg.315105014.
Zotero 插件