Department of Vascular Surgery and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, 37 Guo Xue Alley, Chengdu, 0086-610041, Sichuan Province, China.
West China-Washington Mitochondria and Metabolism Center, West China Hospital of Sichuan University, 37 Guo Xue Alley, Chengdu, 0086-610041, Sichuan Province, China.
J Otolaryngol Head Neck Surg. 2021 Sep 27;50(1):57. doi: 10.1186/s40463-021-00540-y.
Carotid body tumors (CBTs) are rare neuroendocrine neoplasms, but the prognosis of patients with resected CBTs has seldom been elucidated. This study was conducted to investigate the association between variables, especially sex, and the prognosis of carotid body tumor resection.
This was a large-volume single-center retrospective cohort study. Patients who were diagnosed with CBTs between 2009 and 2020 at our center were analyzed retrospectively. Their preoperative, surgical, and follow-up data were collected, and the association between variables and outcomes of CBT resection was assessed by correlation analysis, multivariate logistic regression, and multivariate Cox regression as appropriate.
A total of 326 patients (66.6% were females) were included. Males developed larger CBTs than females (4.3 ± 1.8 cm vs. 3.8 ± 1.4 cm, P = .003). Males were more likely to develop succinate dehydrogenase B (SDHB) mutations (P = .019) and had worse relapse-free survival rates (P = .024). Although tumor size and Shamblin classification had positive relationships with neurological complications and intraoperative blood loss, they did not affect the overall survival rate of patients, which was only influenced by remote metastasis (P = .007) and local recurrence (P = .008).
Compared to females, males with CBT resection were found to have more SDHB mutations and worse relapse-free survival rates, which may lead to the deterioration of prognosis. Tumor size and Shamblin classification cannot predict the overall survival rate of patients with excised CBTs.
颈动脉体肿瘤（CBT）是罕见的神经内分泌肿瘤，但切除 CBT 患者的预后很少得到阐明。本研究旨在探讨变量（尤其是性别）与颈动脉体肿瘤切除预后的关系。
这是一项大样本量的单中心回顾性队列研究。回顾性分析了 2009 年至 2020 年期间在我院诊断为 CBT 的患者。收集了他们的术前、手术和随访数据，并通过相关分析、多变量逻辑回归和多变量 Cox 回归评估变量与 CBT 切除结果之间的关系。
共纳入 326 例患者（66.6%为女性）。男性的 CBT 比女性大（4.3±1.8cm vs. 3.8±1.4cm，P=0.003）。男性更易发生琥珀酸脱氢酶 B（SDHB）突变（P=0.019），且无复发生存率更差（P=0.024）。尽管肿瘤大小和 Shamblin 分级与神经并发症和术中出血量呈正相关，但它们并不影响患者的总生存率，总生存率仅受远处转移（P=0.007）和局部复发（P=0.008）影响。
与女性相比，接受 CBT 切除术的男性更易发生 SDHB 突变，无复发生存率更差，这可能导致预后恶化。肿瘤大小和 Shamblin 分级不能预测切除 CBT 患者的总生存率。
